Publications by authors named "Cornelia Liepke"
Article Synopsis
- Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is involved in both glycolysis and other processes like transcription and apoptosis, and a specific peptide fragment from it (hGAPDH 2-32) was isolated from human placental tissue showing antimicrobial properties.
- This peptide can enter Candida albicans cells and triggers apoptosis, effectively killing the yeast in a dose-dependent manner, with higher concentrations resulting in greater cell depolarization.
- Additionally, hGAPDH (2-32) reduces tissue damage during infections and enhances immune responses by increasing certain cytokines and receptor expression, suggesting that combining it with traditional antifungals could lead to better treatment outcomes for fungal infections.
Human hemoglobin-derived peptides exhibit antimicrobial activity: a class of host defense peptides.
J Chromatogr B Analyt Technol Biomed Life Sci
July 2003
Hemoglobin is a known source of biologically active peptides with various functions. In the present study, we report for the first time the existence of natural processed hemoglobin fragments exhibiting antimicrobial activity in humans. Two antimicrobial hemoglobin-derived peptides were purified from a human placental peptide library by consecutive chromatographic steps tracking the maximum growth inhibitory activity against Escherichia coli BL21.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers identified specific peptides in human milk that promote the growth of bifidobacteria, isolating them from proteins like lactoferrin and the soluble polyimmunoglobulin receptor.
- * A small peptide designed based on these findings, known as PRELP-I, was shown to effectively stimulate bifidobacteria growth, highlighting the dual benefits of human milk in enhancing beneficial bacteria while reducing harmful microbes.