Publications by authors named "Cornel Burger"
Article Synopsis
- The study focused on creating nano-emulsions with natural oils to enhance the topical delivery of three active pharmaceutical ingredients (APIs): clofazimine (CLF), artemisone (ATM), and decoquinate (DQ).
- The formulation demonstrated effective skin penetration and showed no toxicity to human keratinocyte cells, alongside the ability to inhibit Mycobacterium tuberculosis in lab tests.
- These findings suggest that natural oil nano-emulsions could serve as a supplementary treatment for cutaneous tuberculosis (CTB).
Background: In recent years, colloidal delivery systems based on nano-emulsion are gaining popularity; being used for encapsulation and delivery of many drugs. This review therefore aims at summarizing various methods of nano-emulsion formulation and their use as a topical and transdermal delivery vehicle for a number of active pharmaceutical ingredients from different pharmacological classes.
Methods: This article represents a systematic review of nano-emulsions for topical and transdermal drug delivery.
Wiechers' programme "Formulating for Efficacy" initiated a new strategy to optimise the oil phase of topical formulations in order to achieve optimal transdermal drug delivery. This new approach uses the "Delivery Gap Theory" on any active pharmaceutical ingredients (APIs) to test if it could enhance transdermal drug delivery. The aim of the study was to formulate six different semi-solid formulations (three creams and three emulgels) with 2% pravastatin as the API in order to investigate the "Delivery Gap Principle", by determining which formulation would deliver pravastatin best to the target-site (system circulation).
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