Publications by authors named "Cornejo-Juarez P"
Candidemia is the predominant form of invasive candidiasis and the most frequently occurring serious fungal infection in critically ill patients in Intensive Care Units (ICU). Studies carried out in Latin America reveal a higher incidence of candidemia and higher mortality rates when compared to North America or Europe. This highlights the need to develop guidelines for correctly diagnosing and treating candidemia in critically ill patients in the ICU.
View Article and Find Full Text PDFArticle Synopsis
- Patients with cancer have a higher risk of developing infective endocarditis (IE), which can lead to worse health outcomes.
- A retrospective study conducted in Mexico City from 2006 to 2022 matched 36 cancer patients with 72 controls without cancer to identify factors related to IE.
- Key risk factors for IE in cancer patients included obesity, recent surgery, and invasive procedures, with S. aureus infections linked to a higher incidence of systemic embolization, although mortality rates were similar between both groups.
Introduction: Kaposi sarcoma (KS) is an angioproliferative disease caused by human herpesvirus 8 and is mediated by cytokines in an immunodeficient environment. This study aimed to compare IL-6, IL-10, and TNFα levels among patients with AIDS with disseminated KS (DKS), treatment naïve patients living with HIV without DKS, and healthy controls. Secondary outcomes were to compare cytokines levels in patients with DKS and unfavorable outcomes, and an analysis of the behavior of cytokines over time.
View Article and Find Full Text PDFBackground: Fungemia due to uncommon fungi and secondary to multiple risk factors has become an emergent health problem, particularly in oncology patients.
Aims: This study shows the following data collected during an 11-year period in a tertiary care oncologic center from patients with fungemia: demographic data, clinical characteristics, and outcome.
Methods: A retrospective study was performed at Instituto Nacional de Cancerología, a 135-bed referral cancer center in Mexico City, from July 2012 to June 2023.
The metagenomic surveillance of antimicrobial resistance in wastewater has been suggested as a methodological tool to characterize the distribution, status, and trends of antibiotic-resistant bacteria. In this study, a cross-sectional collection of samples of hospital-associated raw and treated wastewater were obtained from February to March 2020. Shotgun metagenomic sequencing and bioinformatic analysis were performed to characterize bacterial abundance and antimicrobial resistance gene analysis.
View Article and Find Full Text PDFPurpose: Patients with hematologic malignancies (HM) are at high risk of invasive lung fungal infections (ILFI). To describe the main characteristics, treatment, and outcomes for five years in adult patients with HM and fungal pneumonia.
Methods: We conducted a retrospective study at Instituto Nacional de Cancerología (INCan), a referral tertiary care oncology hospital with 135 beds in Mexico City, Mexico.
Introduction: Percutaneous nephrostomy tubes (PNT), which are used in some cancer hospitals, are associated with an increase in urinary tract infections (UTI).
Objective: To determine the impact of a standardized care program on the incidence of UTIs requiring hospitalization (UTI-RH).
Material And Methods: Retrospective study that included patients with a first PNT inserted.
The objective of the study was to detect multidrug-resistant sp. and sp. isolates in municipal and hospital wastewater and to determine their elimination or persistence after wastewater treatment.
View Article and Find Full Text PDFIntroduction: Patients with severe neutropenia who develop septic shock (SS) have high mortality. This study aimed to evaluate the risk factors and mortality of SS in patients with HM and febrile neutropenia.
Methodology: We included all patients with hematological malignancies (HM) who presented fever and severe neutropenia, admitted to an oncological tertiary care center in Mexico City for one year.
Article Synopsis
- A comprehensive analysis of 356 Klebsiella pneumoniae species complex isolates revealed three main types: classical (cl), presumptive hypervirulent (p-hv), and hypermucoviscous-like (hmv-like), with the majority being classical at 82.3%.
- Most classical isolates produced extended-spectrum-β-lactamases (ESBLs), and a small percentage showed colistin resistance, while all p-hv strains were antibiotic-susceptible.
- The study found significant differences in capsule production between the different types, which affected virulence, and highlighted the emergence of atypical hypervirulent strains in the population, emphasizing the importance of tracking these pathogens in Mexican healthcare settings.
Background: Phase III clinical trials have documented the efficacy of the SARS-CoV-2 vaccines in preventing symptomatic COVID-19. Nonetheless, it is imperative to continue analyzing the clinical response to different vaccines in real-life studies. Our objective was to evaluate the effectiveness of five different vaccines in hospitalized patients with COVID-19 during the third COVID-19 outbreak in Mexico dominated by the Delta variant.
View Article and Find Full Text PDFFusarium species represent an opportunistic fungal pathogen. The data in Mexico about Fusarium infections in humans are scarce. Here, we present a retrospective series of patients with a confirmed diagnosis of fusariosis in eight different hospitals in Mexico from January 2010 to December 2019.
View Article and Find Full Text PDFCancer patients with infection (CDI) are at a higher risk for adverse outcomes. In addition, a high prevalence of asymptomatic colonization (CDAC) has been reported in this vulnerable population. The molecular characteristics and potential role of CDAC in healthcare-related transmission in the cancer population have been poorly explored.
View Article and Find Full Text PDFArticle Synopsis
- High levels of HHV-8 viral load in patients with Kaposi Sarcoma (KS) can lead to Severe Immune Reconstitution Inflammatory Syndrome (Severe-IRIS-KS) after starting combination antiretroviral therapy (cART), which increases mortality rates, especially in those with lung issues.
- A clinical trial compared the effects of starting valganciclovir, an anti-HHV-8 drug, before cART versus cART alone in AIDS patients with disseminated KS.
- Results showed that while overall mortality was similar between the two groups after 48 weeks, none in the experimental group (EG) died from Severe-IRIS-KS, compared to three in the control group (CG),
Objective: Hospital-acquired infection (HAI) rates were negatively affected by the the coronavirus disease 2019 (COVID-19) pandemic. We describe the incidence of HAIs, main pathogens, and multidrug-resistant organisms (MDROs) isolated in cancer patients before and during the pandemic.
Design: This retrospective, comparative study included patients with HAIs.
Introduction: Oncologic patients can have severe infections due to Aeromonas. This study aims to investigate the clinical characteristics and outcomes of cancer patients with bloodstream infections (BSI) caused by Aeromonas.
Methodology: We included patients with bacteremia caused by Aeromonas species from 2011 to 2018.
Background: Candida bloodstream infection (CBSI) is a growing problem among patients with cancer.
Aim: To describe the main clinical and microbiological characteristics in patients with cancer who suffer CBSI.
Methods: We reviewed the clinical and microbiological characteristics of all patients with CBSI diagnosed between January 2010 and December 2020, at a tertiary-care oncological hospital.
Background: People living with HIV(PLWH) and cancer are among the most vulnerable patients and require constant access to medical services. We compared the characteristics of PLWH and cancer in Mexico, before and during the COVID-19 pandemic.
Methods: Patients admitted 1 year before (pre-pandemic) and 1 year after the start of the pandemic (pandemic) were included.
The objective of this study was to determine the presence and persistence of antimicrobial-resistant enterobacteria and their clonal distribution in hospital wastewater. A descriptive cross-sectional study was carried out in wastewater from two Mexico City tertiary level hospitals. In February and March of 2020, eight wastewater samples were collected and 26 isolates of enterobacteria were recovered, 19 (73.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to analyze the presence and persistence of carbapenemase-producing bacteria in wastewater from two hospitals in Mexico, focusing on various bacterial isolates from treated and untreated wastewater.
- Out of 30 bacterial isolates examined, a high resistance rate (80%) to cephalosporins and carbapenems was found, with resistance genes identified using PCR and a variety of molecular typing methods.
- The research highlights the importance of monitoring hospital wastewater for antimicrobial resistance, which can serve as an early detection system for potential outbreaks and difficult infections.
Introduction: Clostridioides difficile infection (CDI) is recognized as the leading cause of nosocomial diarrhea. This study describes CDI's clinical characteristics, risk factors, and outcomes in the cancer population.
Methods: We conducted a case-control study on cancer patients from 2015-2018 at the Instituto Nacional de Cancerologia in Mexico.
Background: Literature on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in cancer patients is scarce in Latin America. This population seems to have a higher risk for adverse outcomes. This study aims to correlate clinical characteristics with outcomes in patients with cancer.
View Article and Find Full Text PDFObjective: Chronic Lower Limb Lymphedema (CL-LL) secondary to Kaposi sarcoma (KS) has not been recognized as a risk factor for cellulitis. The aim was to describe the clinical spectrum and use of antimicrobial prophylaxis in patients with cellulitis and CL-LL due to KS.
Methods: HIV patients with KS, CL-LL, and at least one episode of cellulitis seen at the AIDS Cancer Clinic at INCan in Mexico from 2004 to 2019 were included.
Purpose: To describe the antimicrobial use in four tertiary care hospitals in Mexico.
Patients And Methods: Point prevalence surveys (PPSs) were conducted on medical records of hospitalized patients with prescribed antimicrobials (AMs) in four tertiary care hospitals in Mexico in 2019. Prevalence estimates and descriptive statistics were used to present the collected data on antimicrobial prescribing and microbiological studies.
Purpose: The aim of this study was to evaluate the demographic characteristics, clinical and pathological factors, and the outcome of cancer and COVID-19 patients in Mexico.
Patients And Methods: A prospective, multicentric study was performed through a digital platform to have a national registry of patients with cancer and positive SARS-CoV-2 test results through reverse transcription quantitative polymerase chain reaction (RT-qPCR). We performed the analysis through a multivariate logistic regression model and Cox proportional hazard model.