Publications by authors named "Coriolano Cruz-Perera"
This study aimed to investigate obesity-related glomerulopathy (ORG) at cellular, structural, and transcriptomic levels. Thirty Wistar rats were randomized into two groups: 15 rats were fed with a standard diet (SD-rats), and 15 rats were fed with a high-fat diet (HFD-rats). After 10 weeks, the weight, kidney function, histological features, and transcriptomic changes were assessed.
View Article and Find Full Text PDFMeasured and Estimated Glomerular Filtration Rate to Evaluate Rapid Progression and Changes over Time in Autosomal Polycystic Kidney Disease: Potential Impact on Therapeutic Decision-Making.
Int J Mol Sci
May 2024
Article Synopsis
- Autosomal polycystic kidney disease (ADPKD) is a genetic condition leading to kidney failure, with tolvaptan being the only approved treatment, but it's only for those with rapid disease progression.
- A study assessed the accuracy of estimating GFR decline through serum creatinine and cystatin-C formulas, noting poor agreement with actual measured GFR declines using iohexol clearance.
- This discrepancy means that about 37% of rapid GFR declines were missed, and many stable cases were wrongly identified as rapid progressors, which could lead to incorrect treatment decisions for tolvaptan therapy.
The error of estimated glomerular filtration rate (eGFR) and its consequences in predialysis are unknown. In this prospective multicentre study, 315 predialysis patients underwent measured GFR (mGFR) by the clearance of iohexol and eGFR by 52 formulas. Agreement between eGFR and mGFR was evaluated by concordance correlation coefficient (CCC), total deviation index (TDI) and coverage probability (CP).
View Article and Find Full Text PDFBackground: Post-transplant diabetes mellitus (PTDM) beyond 12 months (late PTDM) is a severe complication after renal transplantation. Late PTDM develops mostly in subjects with prediabetes. Although exercise may have a potential role in preventing late PTDM, there are no previous data on the effect of exercise in patients with prediabetes.
View Article and Find Full Text PDFBackground: Autosomal dominant polycystic kidney disease (ADPKD) causes about 10% of cases of end stage renal disease. Disease progression rate is heterogeneous. Tolvaptan is presently the only specific therapeutic option to slow kidney function decline in adults at risk of rapidly progressing ADPKD with chronic kidney disease (CKD) stages 1-4.
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