Publications by authors named "Corinne Millardet"
Postoperative SBRT in the treatment of early-stage oropharyngeal and oral cavity cancers with high-risk margins: A dosimetric comparison of volumetric modulated arc therapy with or without non-coplanar arcs and acute toxicity outcomes from the STEREOPOSTOP GORTEC 2017-03 phase 2 trial.
Clin Transl Radiat Oncol
January 2023
Background And Purpose: The STEREO POSTOP GORTEC 2017-03 phase 2 trial (NCT03401840) evaluates postoperative stereotactic body radiotherapy (SBRT) in case of high-risk margins for pT1-T2/N0 oropharyngeal and oral cavity tumors. The present ancillary study aimed to compare the dosimetric impact of adding non-coplanar arcs to the volumetric modulated arc therapy (VMAT) technique and to evaluate acute toxicities on the first patients included in this trial.
Materials And Methods: Ten patients were included.
Article Synopsis
- The study focuses on treating early-stage oropharyngeal and oral cavity cancer using a method called SBRT, especially for patients with high-risk margins after surgery.
- It’s a clinical trial involving 90 patients to see if this new radiation treatment causes fewer severe side effects over two years compared to traditional methods.
- The trial started in 2018 and will continue until January 2024, and they're checking various effects like survival rates and quality of life for the patients.
Purpose: Dosimetry for melanoma-targeted radionuclide therapy (TRT) with [ I]ICF01012, a melanin ligand, has been previously evaluated in mice bearing melanomas. In this study, activity distribution and dosimetry are performed on healthy rabbits (Fauve de Bourgogne) using SPECT-CT imaging and ex vivo measurements.
Material And Methods: Ex vivo biodistribution (i.
Unlabelled: A multi-centre trial using PET requires the analysis of images acquired on different systems We designed a multi-centre trial to estimate the value of 18F-FLT-PET to predict response to neoadjuvant chemotherapy in patients with newly diagnosed breast cancer. A calibration check of each PET-CT and of its peripheral devices was performed to evaluate the reliability of the results.
Material And Methods: 11 centres were investigated.