Publications by authors named "Corinne Isnard Bagnis"

Cancer treatments have been dramatically modified by the introduction and the development of immunological checkpoint inhibitors (ICI). These treatments have many side effects, including acute kidney injury (AKI). Their combination with other treatments makes the diagnosis complex.

View Article and Find Full Text PDF

Purpose: Onco-nephrology is an emerging subspecialty aiming to better understand and prevent renal events in cancer patients. We assessed patients' knowledge about (1) oncological/hematological treatments induced renal toxicity and (2) kidney protective measures.

Methods: Adult patients receiving systemic anti-tumor treatments in multiple day hospital units in France answered a self-administered questionnaire about their knowledge and expectations related to treatment-associated renal toxicity.

View Article and Find Full Text PDF

Anaemia is common in chronic kidney disease (CKD) and has a significant impact on quality of life (QoL), work productivity and outcomes. Current management includes oral or intravenous iron and erythropoiesis-stimulating agents (ESAs), to which hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) have been recently added, increasing the available therapeutic options. In randomised controlled trials, only intravenous iron improved cardiovascular outcome, while some ESAs were associated with increased adverse cardiovascular events.

View Article and Find Full Text PDF

Teaching the principles of participatory design to students mainly interested in digital skills is important because user-centered approaches have become essential in the field of new technologies when we want to guarantee that a product will meet the needs of its end-users. Working with technologies dedicated to the disability assistance was considered to be the right application domain. In 2021, ESIEE Paris, a school training students to become engineers with digital skills, created and opened a new teaching module to learn how to follow the principles of participatory design to improve the quality of a project.

View Article and Find Full Text PDF

Introduction: The number of cancer patients receiving long-term hemodialysis (HD) is increasing, and HD could jeopardize treatments' safety and efficacy. Therefore, managing anticancer drugs is critical in this frail population. In addition, evidence of HD safety or risk is regularly released both for cytotoxic chemotherapy (CT) or hormone therapy (HT) as well as new therapies with molecularly targeted therapies (MTT), immune checkpoint inhibitors (ICI), and a summary of current knowledge is needed.

View Article and Find Full Text PDF

Background: Compassion is a key component of quality care. Encouraging Health Care Professionals (HCPs) to develop a patient-centered care relationship through mindfulness and compassion training may be beneficial for both patients and HCPs.

Method: We assessed the impact of a compassion-centered mindfulness program [i.

View Article and Find Full Text PDF

Introduction: Multi-receptor tyrosine kinase inhibitors with anti-angiogenic activity, particularly lenvatinib, have become the standard treatment for radioiodine-refractory metastatic differentiated thyroid cancer but are associated with a high incidence of toxicity. Although patients treated with lenvatinib have been shown to have a significant improvement in progression-free survival, lenvatinib-associated toxicity may result in dose reductions, dose interruptions or even complete lenvatinib withdrawal, compromising anti-tumor efficacy.

Areas Covered: The article covers the main cardiological and renal toxicities of lenvatinib, including hypertension, prolonged QT interval, heart failure, arterial and venous thromboembolic events, proteinuria and renal failure, and proposes appropriate management of these events during lenvatinib therapy.

View Article and Find Full Text PDF
Article Synopsis
  • Renal complications are common in cancer patients, leading to the emergence of onco-nephrology, a subspecialty that focuses on this intersection, although its scope is not well defined.
  • A study conducted through anonymous online surveys gathered insights from 228 physicians, revealing that nephrologists and oncologists felt moderately confident (around 6/10) in handling onco-nephrological cases, but many believed their training and resources were inadequate.
  • The results highlighted a significant demand for better resources and guidelines, leading to the establishment of a national working group, GRIFON, to address these gaps in onco-nephrology practice in France.
View Article and Find Full Text PDF

Genetic renal phosphate leak is one of the rare disorders in recurrent stone formers with absorptive hypercalciuria. Diagnosis and appropriate management may change the life of patients. To provide answers on how and when to make the diagnosis of genetic renal phosphate leak and how medical management prevents the recurrences and changes patients' life, we conducted a retrospective study including nine patients with recurrent nephrolithiasis and a confirmed genetic mutation of a phosphate transporter between 2008 and 2019 in our multidisciplinary center at the Pitié Salpetriere Hospital, Paris, France.

View Article and Find Full Text PDF
Article Synopsis
  • * It found no significant changes in kidney function (plasma creatinine and glomerular filtration rate) after discontinuation of CsA in most patients, suggesting reversibility of CsA-induced nephrotoxicity.
  • * Additionally, the treatment showed effectiveness in resolving cystoid macular edema in a majority of patients over long-term follow-up, without significant changes in best-corrected visual acuity.
View Article and Find Full Text PDF

Epidemiology and risk factors for kidney damage during chemotherapy Cancer and kindey are closely related with 12 to 25% of cancer patients exhibiting chronic kidney disease. During cancer treatment, almost one third of the patients, whatever their baseline glomerular filtration rate will experience acute renal failure. Therefore, it is critical to precisely estimate renal functions, adapt drug dosage to glomerular filtration rate, and prevent chemotherapy induced renal toxicity.

View Article and Find Full Text PDF

Rationale & Objective: Pauci-immune necrotizing glomerulonephritis (PING) is usually associated with the presence of antineutrophil cytoplasmic antibodies (ANCA). However, a minority (2%-3%) of patients with PING do not have detectable ANCA. We assessed the clinical spectrum and outcome of patients with ANCA-negative PING.

View Article and Find Full Text PDF
Article Synopsis
  • Cardiovascular diseases are a major cause of death, but many cases can be prevented.
  • The VIVOPTIM program was created by a health insurance company in France to help people manage their heart health through personalized support and digital tools.
  • From the program, many participants showed positive changes in their health like lower blood pressure, reduced weight, and more daily exercise, leading to the program being expanded across France in 2018.
View Article and Find Full Text PDF

Chronic kidney disease (CKD) is a comorbidity of major clinical significance amongst people living with HIV (PLWHIV) and is associated with significant morbidity and mortality. The prevalence of CKD is rising, despite the widespread use of antiretroviral therapy (ART) and is increasingly related to prevalent non-infectious comorbidities (NICMs) and antiretroviral toxicity. There are great disparities evident, with the highest prevalence of CKD among PLWHIV seen in the African continent.

View Article and Find Full Text PDF

BACKGROUNDProteinuria is considered an unfavorable clinical condition that accelerates renal and cardiovascular disease. However, it is not clear whether all forms of proteinuria are damaging. Mutations in CUBN cause Imerslund-Gräsbeck syndrome (IGS), which is characterized by intestinal malabsorption of vitamin B12 and in some cases proteinuria.

View Article and Find Full Text PDF

Action myoclonus - renal failure is a rare syndrome associated with a progressive myoclonic epilepsy and renal impairment that may lead to end-stage renal failure. It is an autosomal recessive genetic disease related to a loss-of-function mutation in SCARB2, which encodes for lysosomal integral membrane protein type 2. Renal involvement is poorly described, and we report here the first electron microscopy renal analysis after having performed a kidney biopsy in a 31-year-old Gambian patient.

View Article and Find Full Text PDF

We compared access to a kidney transplantation (KT) waiting list (WL) and to KT between people living with HIV (PLHIV) and HIV-uninfected controls. Using the REIN (the national Renal Epidemiology and Information Network registry), we included all PLHIV initiating dialysis in France throughout 2006-2010 and HIV-uninfected controls matched for age, sex, year of dialysis initiation, and the existence of a diabetic nephropathy. Patients were prospectively followed until December 2015.

View Article and Find Full Text PDF

Objectives: Patient's perception analysis appears recently in numerous studies. Conjoint analysis has been used extensively by market researchers for studying how people value the characteristics of products and services. This technique was used in a clinical study to describe perceptions and preferences of anaemic patients suffering from chronic kidney disease not on dialysis (CKDnd), regarding erythropoietin stimulating agents (ESA).

View Article and Find Full Text PDF

Background: Human immunodeficiency virus (HIV) is associated with diverse glomerular diseases. Characteristics of minimal change nephrotic syndrome (MCNS) in this setting have been little studied, and the specific features of this uncommon association remain to be determined.

Methods: We conduct a retrospective study.

View Article and Find Full Text PDF

Background: Calciphylaxis or calcific uremic arteriolopathy (CUA) is a cutaneous disease with ulcerations secondary to calcification of cutaneous and subcutaneous small arteries and arterioles. It is a rare but severe disease with significant morbidity and mortality affecting 1 to 4% of dialysis patients. The circumstances of occurrence are multiple.

View Article and Find Full Text PDF