Publications by authors named "Corinne Girard"

Ethnopharmacological Relevance: Fruits of Nitraria sibirica Pall. are traditionally used in Uighur medicine to treat hypertension. This study aimed to support that folk use by defining their vasoactive and hypotensive properties.

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Aim Of The Study: The stem bark of Terminalia superba (Combretaceae) (TS) is used in traditional Cameroonian medicine as antihypertensive remedy. The aim of this study was to investigate the hypotensive and the antihypertensive effects of the aqueous extract of the stem bark of Terminalia superba.

Materials And Methods: Hypertension was obtained in rats by oral administration of 10% D-glucose for 3 weeks.

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Aim Of The Study: Ziziphora clinopodioides Lam. (ZC) is widely used in Uyghur folk medicine for the treatment of hypertension diseases in Xinjiang, an autonomous region of China. To provide pharmacological basis for this traditional use, we explored the vasodilating effects of ZC and investigated the underlying mechanisms.

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Aim Of The Study: The stem bark of Terminalia superba (Combretaceae) (TS) is used in traditional Cameroonian medicine as antihypertensive remedy. In the present study, we investigated the vasorelaxant properties of different extracts of TS and their underlying mechanisms.

Materials And Methods: Activities of aqueous (AQU), methanolic (MET), methylene chloride (MC), and methylene chloride-methanol (MCM) extracts of TS were evaluated on isolated rat aortic rings precontracted with phenylephrine (PE) or high KCl.

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A screening of Greek Fabaceae extracts identified the methanolic extract of Podocytisus caramanicus Boiss. & Heldr. as having proliferative activity on human breast cancer cells (MCF-7).

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Flavonoids and coumarins are naturally occurring compounds that are widely distributed in vegetables and have a broad pharmacological activity. Inducibility of UDP-glucuronosyltransferases (UGTs) by xenobiotics is well documented and can be considered beneficial for health. In particular, UGT1A1-dependent bilirubin conjugation plays a critical role in the detoxification of neurotoxic bilirubin and phenobarbital-mediated UGT1A1 induction therapy is commonly used in the treatment of unconjugated hyperbilirubinemic diseases such as Crigler-Najjar type II disease.

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Article Synopsis
  • Phebaclavin I, a new type of 3-prenylated coumarin, was discovered in the plant Phebalium aff. tuberculosum, along with five other similar compounds.
  • The structure of phebaclavin I was determined using various spectroscopic techniques.
  • Additionally, several known coumarins were found, including trichoclin acetate, which is reported here for the first time from a natural source despite being previously described through a synthetic process.
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We report here the synthesis of aromatic coumarins and aromatic alpha-quinolones which were evaluated in vitro for their protective potentialities against tert-butyl hydroperoxide (t-BHP)-induced oxidative damage on human liver cell death, i.e., human hepatoma HepG2 cell line and human hepatocytes in primary culture.

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The aerial parts of Phebalium clavatum yielded eight new 3-prenylated coumarins, phebaclavin A-H (1-8). Their structures were established on the basis of their NMR and mass spectral data. In addition, seven known compounds were also isolated, including two 8-geranyloxy linear furocoumarins previously obtained from Phebalium tuberculosum ssp.

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Article Synopsis
  • - Phebarudol is a new compound derived from the twigs of the plant Phebalium rude, specifically its subspecies amblycarpum.
  • - This compound is a type of prenylated p-coumarate and was found alongside two other known related compounds, werneria chromene and methyl demethoxywutaiensate.
  • - The structure of phebarudol was determined using various spectroscopic techniques.
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