Atazanavir in pregnancy: impact on neonatal hyperbilirubinemia.

Objective: To study the impact on the neonate of maternal antiretroviral therapy with atazanavir (ATV).

Study Design: An observational study of 22 HIV-infected women receiving, for clinical indications, antiretroviral therapy with ATV 300 mg and ritonavir 100mg during pregnancy and their 23 HIV infants (including a twin pair).

Results: Mothers had received ATV for a median duration of 19 months [range 3-49] by delivery.

Perinatal care and outcome of fetuses with trisomies 13 and 18 following a parental decision not to terminate the pregnancy.

Objective: To describe pregnancy outcomes of fetuses affected by trisomies 13 and 18 following prenatal diagnosis and a decision to continue the pregnancy.

Material And Methods: A single-center, retrospective study of 34 cases with a diagnosis or strong suspicion of trisomy 13 or 18.

Results: Fourteen of 34 (41%) families chose to continue the pregnancy after a diagnosis of trisomy 13 or 18 was made.