Cytokine-dependent transcriptional down-regulation of epithelial sodium channel in ulcerative colitis.

Background & Aims: The main limiting factor for sodium absorption in distal colon is the amiloride-sensitive epithelial sodium channel (ENaC). This study aimed to characterize mechanisms involved in the dysregulation of ENaC expression in ulcerative colitis (UC).

Methods: Epithelial preparations from surgically removed inflamed and control sigmoid colons were used.