Assessment of Raman spectroscopy as a fast and non-invasive method for total stratum corneum thickness determination of pig skin.

Determination of total stratum corneum (SC) thickness is necessary to construct accurate SC drug concentration depth profiles that are used to evaluate the skin absorption of locally acting active components. Currently, different established methods such as the microscopic or gravimetric approach, estimation via transepidermal water loss or NIR densitometry are used. However, some of them represent time consuming strategies.

Semi-solid fluorinated-DPPC liposomes: Morphological, rheological and thermic properties as well as examination of the influence of a model drug on their skin permeation.

The goal of this study was to investigate the influence of an incorporated model drug on the skin permeation of the vehicle itself as it may affect the microstructure and properties of the applied formulation via molecular interactions. For this purpose, we performed skin permeation studies using liposomes prepared with F-DPPC, a monofluorinated analog of dipalmitoylphosphatidylcholine (DPPC), with and without sodium fluorescein (SoFl) serving as model drug. Interestingly, the liposome preparation with F-DPPC yielded semi-solid opalescent systems.