Publications by authors named "Corinna Draeger"
Aims: The primary objective was to explore whether the suppression of ovarian activity induced by a combined oral contraceptive (COC) is influenced by the simultaneous intake of the selective progesterone receptor modulator (SPRM) vilaprisan (VPR).
Methods: In this exploratory randomized, double-blind, parallel-group study, 71 healthy premenopausal women were randomized (1:1) to receive either 2 mg/d VPR or placebo for 3 months. Concomitantly, a COC (0.
Article Synopsis
- The study aimed to find the lowest effective dose of trimegestone (TMG) using a vaginal ring for inhibiting ovulation among 80 healthy women over 28 days.
- Results showed that the 94 µg/day dose was effective in preventing ovulation, while higher doses had no ovulations and provided better ovarian suppression.
- The TMG vaginal ring was found to be safe and well-tolerated, suggesting it could be a viable future option for progestogen-only contraception with the convenience of monthly insertion.
This randomized, double-blind, parallel-group study in healthy young women investigated the effect of treatment with vilaprisan (0.5, 1, 2, or 4 mg/day for 12 weeks) on ovarian function by assessing the Hoogland score, which is based on the size of follicle-like structures as determined by transvaginal ultrasound and on estradiol and progesterone serum concentrations. Ovulation inhibition (ie, Hoogland score <6 in treatment weeks 1-4 and 8-12) was observed in >80% of the subjects receiving vilaprisan ≥1 mg/day.
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