Effectiveness and Safety of Hair Growth Formulation Containing L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia.

Background: Androgenic alopecia (AGA) is commonly known as male patterned baldness. A high level of dihydrotestosterone (DHT) plays a significant role in AGA development. Inhibition of the enzyme steroid 5-alpha reductase (S5AR), responsible for converting testosterone into DHT, has been shown to delay the progression of AGA.

A colorimetric assay adapted to fragment screening revealing aurones and chalcones as new arginase inhibitors.

Arginase, a difficult-to-target metalloenzyme, is implicated in a wide range of diseases, including cancer, infectious, and cardiovascular diseases. Despite the medical need, existing inhibitors have limited structural diversity, consisting predominantly of amino acids and their derivatives. The search for innovative arginase inhibitors has now extended to screening approaches.

Vasorelaxant and hypotensive effects of an ethanolic extract of and its main compound quercetin 3-methyl ether 3'-O-β-xylopyranoside.

plants were traditionally used to treat diseases associated with endothelial dysfunction. The present study investigated the effects of an ethanolic extract of Willd. (commonly named water lily, WL) and its main compound (quercetin 3-methyl ether 3'-O--xylopyranoside) on vascular function in rats.

Arginase inhibitory activities of chemical constituents from Beille leaves.

The methanolic extract of the leaves of Beille showed arginase inhibitory activity (40% at 100 µg/mL) and was then fractionated to obtain nine polyphenolic compounds. Their structures were elucidated on the basis of NMR spectroscopic data, and by comparison with data previously reported in the literature, as gallic acid (), 3,4-dihydroxybenzoic acid (), chlorogenic acid, (), corilagin (), cynaroside (), cosmosiin (), hyperoside () isoquercitrin ( and guajaverin (). These compounds have been evaluated as arginase inhibitors.

Phosphodiesterase 5 and Arginase Inhibitory Activities of the Extracts from Some Members of Nelumbonaceae and Nymphaeaceae Families.

The objectives of this study were (1) to investigate the effect of extracts from some plants in the families Nelumbonaceae and Nymphaeaceae on phosphodiesterase 5 (PDE5) and arginase, which have been used in erectile dysfunction treatment, and (2) to isolate and identify the compounds responsible for such activities. The characterization and quantitative analysis of flavonoid constituents in the active extracts were performed by HPLC. Thirty-seven ethanolic extracts from different parts of plants in the genus and of Nymphaeaceae and genus of Nelumbonaceae were screened for PDE5 and arginase inhibitory activities.

An Update on Arginase Inhibitors and Inhibitory Assays.

Arginase, which converts arginine into ornithine and urea, is a promising therapeutic target. Arginase is involved in cardiovascular diseases, parasitic infections and through a critical role in immunity, in some cancers. There is a need to develop effective arginase inhibitors and therefore efforts to identify and optimize new inhibitors are increasing.

Mammalian Arginase Inhibitory Activity of Methanolic Extracts and Isolated Compounds from Species.

Polyphenolic enriched extracts from two species of , and , possess mammalian arginase inhibitory capacities, with the percentage inhibition ranging from 80% to 95% at 100 µg/mL and 40% to 64% at 10 µg/mL. Phytochemical investigation of these species led to the isolation and identification of two new natural stilbene oligomers named thunbergin A-B (-), together with three other stilbenes, -resveratrol (), -scirpusin A (), -cyperusphenol A (), and two flavonoids, aureusidin () and luteolin (), which were isolated for the first time from and . Structures were established on the basis of the spectroscopic data from MS and NMR experiments.

Cinnamides Target Arginase Selectively.

Caffeic acid and related natural compounds were previously described as arginase (L-ARG) inhibitors, and against the whole parasite in vitro. In this study, we tested cinnamides that were previously synthesized to target human arginase. The compound caffeic acid phenethyl amide (CAPA), a weak inhibitor of human arginase (IC = 60.

Arginase inhibitory properties of flavonoid compounds from the leaves of Mulberry (Morus alba, Moraceae).

Objectives: We aimed to isolate and identify bioactive molecules from Morus alba (Moraceae) leaves having arginase inhibitory activity towards the combat of clinical outcomes related to endothelial dysfunction.

Method: Extraction and isolation were carried out by successive macerations, prepurification by using a Solid Phase Extraction (SPE) and separation using preparative PLC. The structures of the isolated components were established and confirmed by spectroscopic analyses, including the ESI-HRMS and NMR spectroscopic investigations.

Thin-layer chromatography-bioautographic method for the detection of arginase inhibitors.

Arginase represents a promising therapeutic target for various pathologies including inflammatory, cardiovascular, and parasitic diseases or cancers. In the current work, we report, for the first time, about the development of a thin-layer chromatography-based bioautography which can be used to rapidly detect arginase inhibitors in complex matrices such as plant extracts. The assay is based on the detection of urea produced by arginase using the coloring reagent α-isonitrosopropiophenone, resulting in the formation of a pink background on thin-layer chromatography plates.

Vasorelaxant effects of Crataegus pentagyna: Links with arginase inhibition and phenolic profile.

Ethnopharmacological Relevance: Crataegus leaves, flowers and fruits have been traditionally used to improve blood circulation, numerous preclinical and clinical studies supporting the cardiovascular benefits of Crataegus preparations. In this respect, there is very limited data on Crataegus pentagyna; in addition, the chemical profile of this species is still incompletely elucidated.

Aim Of The Study: The objective of this study was to examine the cardiovascular benefits of Crataegus pentagyna Waldst.

Metabolite profiling, arginase inhibition and vasorelaxant activity of Cornus mas, Sorbus aucuparia and Viburnum opulus fruit extracts.

The present study investigated the effects of Cornus mas, Sorbus aucuparia and Viburnum opulus fruit extracts on arginase activity and arterial vasodilation. V. opulus fruit extract exerted the highest vasorelaxant activity in phenylephrine precontracted rat aortic rings (EC = 6.

Cinnamaldehyde Induces Expression of Efflux Pumps and Multidrug Resistance in Pseudomonas aeruginosa.

Essential oils or their components are increasingly used to fight bacterial infections. Cinnamaldehyde (CNA), the main constituent of cinnamon bark oil, has demonstrated interesting properties against various pathogens, including In the present study, we investigated the mechanisms and possible therapeutic consequences of adaptation to CNA. Exposure of PA14 to subinhibitory concentrations of CNA caused a strong albeit transient increase in the expression of operons that encode the efflux systems MexAB-OprM, MexCD-OprJ, MexEF-OprN, and MexXY/OprM.

The role of arginase in aging: A systematic review.

Aging is a normal, progressive and multi-step degeneration in the physiological functions and metabolic processes of living organisms until death. It represents the main risk factor for many diseases (e.g.