Publications by authors named "Corina Seiman"

Along with the progress of nanoscience and nanotechnology came the means to synthesize nanometric scale materials. While changing their physical and chemical properties, they implicitly changed their application area. The aim of this paper was the synthesis of colloidal silver nanoparticles (Ag-NPs by ultrasonic disruption), using soluble starch as a reducing agent and further as a stabilizing agent for produced Ag-NPs.

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Background: During the current SARS-CoV-2 pandemic, the identification of effective antiviral drugs is crucial. Unfortunately, no specific treatment or vaccine is available to date.

Objective: Here, we aimed to predict the interactions with SARS-CoV-2 proteins and protein targets from the human body for some flavone molecules (kaempferol, morin, pectolinarin, myricitrin, and herbacetin) in comparison to synthetic compounds (hydroxychloroquine, remdesivir, ribavirin, ritonavir, AMD-070, favipiravir).

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Article Synopsis
  • Chromosome segregation accuracy in normal cells relies on mitosis mechanics and the spindle assembly checkpoint (SAC) proteins, particularly Mad1 and Mad2.
  • Mad1 and Mad2 are essential for preventing incorrect cell divisions that lead to aneuploidy, which can trigger genetic disorders and cancer development.
  • Research into the structural and functional details of SAC proteins highlights that even small changes in Mad1 and Mad2 can cause aneuploidy, suggesting potential new avenues for genetic medicine.
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A comparative study of 36 molecular descriptors derived from the topological distance matrix and van der Waals space is carried out within this paper. They are partitioned into 16 generalized topological distance matrix indices, 11 topological distance indices known in the literature (seven obtained from eigenvalues/eigenvectors of distance matrix), and 9 van der Waals molecular descriptors. The generalized topological distance indices, (k)delta(lambda) (lambda = 1 - 3, k = 1 - 4), are introduced in this work on the basis of reciprocical distance matrix.

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