Publications by authors named "Corina Sandulescu"
Article Synopsis
- The development of resistance to platinum drugs, particularly in ovarian cancer, is a major challenge for effective treatment, and altered pH levels in tumor cells contribute to this resistance.
- The study reveals that V-ATPase-V0a2, a specific proton pump isoform, is over-expressed in cisplatin-resistant ovarian cancer cells, facilitating tumor invasion through acidification and immune modulation.
- Targeting V-ATPase-V0a2 can enhance the sensitivity of these resistant tumors to cisplatin and carboplatin, potentially offering a new therapeutic approach by reducing pH levels and improving DNA damage response.
In the zebrafish olfactory epithelium, three morphologically distinct olfactory neurons express different marker proteins. We utilize this feature to access developmental dynamics of one of the neuron types, the crypt cells, to determine whether they are differentiated at a stage similar to other olfactory neurons. Immunohistochemical studies using an S100 antibody that specifically recognizes crypt cells showed that S100-positive cells appear in olfactory rosettes as early as at 2day postfertilization (dpf).
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