Pregnancy outcomes in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohorts.

Purpose: To conduct a systematic review and meta-analysis to quantify the incidence of congenital malformations (CMs) and other pregnancy outcomes as a function of in utero anti-epileptic drug (AED) exposure.

Methods: We performed a systematic literature review to identify all published registries and cohort studies of births from pregnant women with epilepsy (WWE) that reported incidence of CMs. Overall incidences were calculated using a random effects model.

Efficacy and safety of erythropoiesis-stimulating proteins in myelodysplastic syndrome: a systematic review and meta-analysis.

Objective: The objective was to assess the efficacy and safety of erythropoiesis-stimulating proteins (ESPs) in anemia of myelodysplastic syndrome (MDS).

Method: A systematic review and meta-analysis was conducted covering English-language studies published from 1980 to December 2005.

Results: Fifty-nine studies qualified: five controlled trials (n = 354), all epoetin versus control (EvC); 51 epoetin single-arm studies (n = 1,650); and three darbepoetin single-arm studies (n = 102).

The natural history and prognosis of neovascular age-related macular degeneration: a systematic review of the literature and meta-analysis.

Purpose: To describe the natural history and progression of visual loss in eyes with untreated neovascular age-related macular degeneration (AMD).

Design: Systematic review and meta-analysis.

Participants: Four thousand three hundred sixty-two untreated neovascular AMD patients from published interventional studies.