Publications by authors named "Corey G K Flynn"
The metabolic switch from glycolysis to fatty acid oxidation in postnatal cardiomyocytes contributes to the loss of the cardiac regenerative potential of the mammalian heart. However, the mechanisms that regulate this metabolic switch remain unclear. The protein kinase complex mechanistic target of rapamycin complex 1 (mTORC1) is a central signaling hub that regulates cellular metabolism and protein synthesis, yet its role during mammalian heart regeneration and postnatal metabolic maturation is undefined.
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- Interstitial stromal cells are essential for muscle development and repair, with specific expression of Hoxa11 and Hoxd11 important for muscle patterning during embryonic stages.
- Hoxa11-CreERT2 lineage tracing shows these cells contribute to muscle fibers in adulthood, surpassing contributions from traditional satellite cells.
- Isolated Hoxa11-expressing interstitial cells cannot form myotubes on their own, but can assist in the differentiation of myotubes, indicating they act as muscle progenitors rather than stem cells.