Publications by authors named "Corentin Pasquier"
Background: The optimal modalities of radiotherapy when combining concurrent chemoradiation (CCRT) and immunotherapy (IO) for locally advanced non-small cell lung cancer (LA-NSCLC) remain to be determined. The aim of this study was to investigate the impact of radiation on different immune structures and immune cells in patients treated with CCRT followed by durvalumab.
Material And Methods: Clinicopathologic data, pre- and post-treatment blood counts, and dosimetric data were collected in patients treated with CCRT and durvalumab consolidation for LA-NSCLC.
Background: Management of macroscopic local recurrence (MLR) after radical prostatectomy is a challenging situation with no standardized approach.
Objective: The objective of our study was to assess the efficacy and safety of functional image-guided salvage radiotherapy (SRT) in patients with MLR in the prostate bed.
Design, Setting, And Participants: In this international multicenter retrospective study across 16 European centers, eligible patients were initially treated by radical prostatectomy (RP) with or without pelvic lymph node dissection for localized or locally advanced adenocarcinoma of the prostate.
Article Synopsis
- Radiotherapy dose escalation, specifically through the addition of high dose-rate brachytherapy (HDR-BB), has been shown to enhance biochemical control in patients with intermediate- to high-risk prostate cancer, as validated by this study involving 709 patients.* -
- After a median follow-up of 62 months, the results revealed a 5-year biochemical control rate of 87.5%, with 91% for intermediate-risk and 85% for high-risk categories, alongside high rates of clinical relapse-free survival and overall survival.* -
- The study concluded that HDR-BB is effective and well-tolerated when used with external beam radiotherapy, and suggests that integrating new hormonal treatments or refined fractionation regimens could