A randomized controlled trial examining general parenting training and family-based behavioral treatment for childhood obesity: The ReFRESH study design.

Family-based behavioral treatment (FBT) is one of the most effective treatments for childhood obesity. These programs include behavior change strategies and basic parenting training to help parents make healthy diet and physical activity changes for their children. While effective, not all families respond to this program.

Radiological outcomes following surgical fixation with wires versus moulded cast for patients with a dorsally displaced fracture of the distal radius: a radiographic analysis from the DRAFFT2 trial.

Aims: The primary aim of this study was to report the radiological outcomes of patients with a dorsally displaced distal radius fracture who were randomized to a moulded cast or surgical fixation with wires following manipulation and closed reduction of their fracture. The secondary aim was to correlate radiological outcomes with patient-reported outcome measures (PROMs) in the year following injury.

Methods: Participants were recruited as part of DRAFFT2, a UK multicentre clinical trial.

A randomised controlled trial of a digital intervention (Renewed) to support symptom management, wellbeing and quality of life in cancer survivors.

Background: Many cancer survivors following primary treatment have prolonged poor quality of life.

Aim: To determine the effectiveness of a bespoke digital intervention to support cancer survivors.

Design: Pragmatic parallel open randomised trial.

Design and Construction of an Experimental Setup to Enhance Mineral Weathering through the Activity of Soil Organisms.

Enhanced weathering (EW) is an emerging carbon dioxide (CO2) removal technology that can contribute to climate change mitigation. This technology relies on accelerating the natural process of mineral weathering in soils by manipulating the abiotic variables that govern this process, in particular mineral grain size and exposure to acids dissolved in water. EW mainly aims at reducing atmospheric CO2 concentrations by enhancing inorganic carbon sequestration.

Maintaining long-term physical activity after cancer: a conceptual framework to inform intervention development.

Purpose: This paper describes a conceptual framework of maintenance of physical activity (PA) and its application to future intervention design.

Methods: Evidence from systematic literature reviews and in-depth (N = 27) qualitative interviews with individuals with cancer were used to develop a conceptual framework of long-term physical activity behaviour. Determinants of long-term PA were listed and linked with domains of the Theoretical Domains Framework which in turn were linked to associated behaviour change techniques (BCTs) and finally to proposed mechanisms of action (MoA).

Case management for integrated care of older people with frailty in community settings.

Background: Ageing populations globally have contributed to increasing numbers of people living with frailty, which has significant implications for use of health and care services and costs. The British Geriatrics Society defines frailty as "a distinctive health state related to the ageing process in which multiple body systems gradually lose their inbuilt reserves". This leads to an increased susceptibility to adverse outcomes, such as reduced physical function, poorer quality of life, hospital admissions, and mortality.

Quality of life and health status in older adults (≥65 years) up to five years following colorectal cancer treatment: Findings from the ColoREctal Wellbeing (CREW) cohort study.

Objective: Colorectal cancer (CRC) is common in older adults, with more than 70% of diagnoses in people aged ≥65 years. Despite this, there is a knowledge gap regarding longer-term outcomes in this population. Here, we identify those older people most at risk of poor quality of life (QoL) and health status in the five years following CRC treatment.

Toward In-Field Determination of Nitrate Concentrations Via Diffusive Gradients in Thin Films-Incorporation of Reductants and Color Reagents.

Diffusive gradients in thin films (DGTs) have been established as useful tools for the determination of nitrate, phosphate, trace metals, and organic concentrations. General use of DGTs, however, is limited by the subsequent requirement for laboratory analysis. To increase the uptake of DGT as a tool for routine monitoring by nonspecialists, not researchers alone, methods for in-field analysis are required.

Self-management by older people living with cancer and multi-morbidity: a qualitative study.

Purpose: Over half of individuals diagnosed with cancer are aged over 70 years, and more than 75% of those with cancer report at least one other medical condition. Having multiple conditions alongside cancer in old age may lower functional status, greater likelihood of treatment complications and less favourable prognoses. This qualitative study explored how older people with long-term chronic conditions manage their health and meet their health-related goals after they have completed treatment for cancer.

The temperature and flow dependence of nitrate concentration and load estimates based on diffusive gradients in thin films.

Concentrations determined using diffusive gradients in thin films (DGT) have been used to derive time-averaged loads in streams and rivers. However, DGT provide time-weighted average concentrations that assume the independence of concentration and flow. Additionally, dynamic and coordinated changes in temperature, flow, and concentration are potential sources of bias in concentration and load calculations.

Evaluation of a multi-sensor Leap Motion setup for biomechanical motion capture of the hand.

The Leap Motion controller (LMC) offers a low-cost means of markerless hand tracking, however, its utility is limited by a small field of view and reliance on appropriate sensor positioning. A recent update from Leap Motion has enabled the use of a multiple LMC device on a single computer, allowing the tracking of hands from multiple orientations, potentially overcoming the aforementioned limitations. This study describes a method of implementing a multi-LMC setup and evaluates its effect on the validity and reliability of the derived kinematics.

Development of bromide-selective Diffusive Gradients in Thin-Films for the measurement of average flow rate of streams.

Diffusive Gradients in Thin-Films (DGT) have traditionally been used to measure time-weighted average concentration in water. We tested whether Br-DGT in combination with the trace-dilution flow rate method, could be used as a new approach for measuring water flow rate. A novel bromide selective DGT based on the Purolite Bromide Plus anion exchange resin (Br-DGT) was developed, which provided environmental bromide concentrations comparable to grab samples.

Exploring maintenance of physical activity behaviour change among people living with and beyond gastrointestinal cancer: a cross-sectional qualitative study and typology.

Objectives: In the last decade, there has been a rapid expansion of physical activity (PA) promotion programmes and interventions targeting people living with and beyond cancer (LWBC). The impact that these initiatives have on long-term maintenance of PA remains under-researched. This study sought to explore the experiences of participants in order to characterise those who have and have not successfully sustained increases in PA following participation in a PA intervention after a diagnosis of gastrointestinal (GI) cancer, and identify barriers and facilitators of this behaviour.

Self-management in older people living with cancer and multi-morbidity: A systematic review and synthesis of qualitative studies.

Objective: Many older people with cancer live with multimorbidity. Little is understood about the cumulative impact of old age, cancer and multimorbidity on self-management. This qualitative systematic review and synthesis aimed to identify what influences self-management from the perspective of older adults living with cancer and multimorbidity.

Exploring the effects of being diagnosed with type 1 diabetes in adolescence.

Type 1 diabetes is a complex long-term condition for which there is no cure. It can have significant consequences for patients, who need to adapt their lives to a demanding regimen of insulin therapy and will be at risk of various health complications, some of which are potentially fatal. A diagnosis of type 1 diabetes may come as a shock and may be challenging for the patient to accept, and when the condition is diagnosed in adolescence it is likely to compound the challenges many young people experience during this crucial developmental period.

Wessex Acute Frailty Audit: applying quality improvement methodology to design and implement a regional frailty audit using a collaborative, multiprofessional approach.

Introduction: An acute hospital stay increases the risk of negative outcomes for those living with frailty. This paper describes the application of quality improvement methodology to design and implement a regional audit to gain an understanding of care provision.

Methods: Small scale tests of change (Plan-Do-Study-Act cycles) were used to design the audit structure and questions.

Utility of 'Diffusive Gradients in Thin-Films' for the measurement of nitrate removal performance of denitrifying bioreactors.

The increase in environmental nutrient availability as a result of human activities has necessitated the development of mitigation strategies for nutrient removal, such as nitrate. Current methods for determining the efficiency of different mitigation strategies required measurement of changes in nitrate concentrations, however, these methods can be expensive or do not account fully for the temporal variability of nitrate concentration. This study evaluated the utility of Diffusive Gradients in Thins-Films (DGT) for determining nitrate removal in two denitrifying bioreactors, and compared DGT performance to traditional approaches for determining performance, including high and low frequency water grab sampling.

The effectiveness of psychological interventions for fatigue in cancer survivors: systematic review of randomised controlled trials.

Background: Fatigue is a common symptom in cancer patients that can persist beyond the curative treatment phase. This systematic review evaluated the effectiveness of psychological interventions for cancer-related fatigue in post-treatment cancer survivors.

Methods: We searched relevant online databases and sources of grey literature.

Outcomes of trimodality bladder-sparing therapy for muscle-invasive bladder cancer.

Introduction: Although radical cystectomy is considered the standard of care for muscle-invasive bladder cancer (MIBC), recent data has suggested comparable survival outcomes for bladder-sparing trimodality therapy (TMT). We conducted a retrospective, single-institution analysis of MIBC patients to evaluate the efficacy of TMT as an alternative, curative approach to surgical intervention.

Methods: We conducted a retrospective analysis of MIBC patients assessed by a multidisciplinary team at the Juravinski Cancer Centre from 2010-2016.

Developing a digital intervention for cancer survivors: an evidence-, theory- and person-based approach.

This paper illustrates a rigorous approach to developing digital interventions using an evidence-, theory- and person-based approach. Intervention planning included a rapid scoping review that identified cancer survivors' needs, including barriers and facilitators to intervention success. Review evidence ( = 49 papers) informed the intervention's Guiding Principles, theory-based behavioural analysis and logic model.