Publications by authors named "Corbett Ouellette"
Article Synopsis
- Group A Streptococcus (GAS) is a significant pathogen that requires iron for survival, with heme being its preferred iron source.
- The study explored the role of the HupZ protein in binding and degrading heme, revealing that HupZ does bind heme but does not coordinate the heme iron directly.
- The findings suggest that HupZ serves an important function in heme metabolism and host survival, potentially acting as a heme chaperone, and is structurally related to another enzyme involved in heme degradation.
The cytokines interleukin-4 (IL-4) and IL-13 bind to their shared receptor subunit IL-4Rα to direct the alternative activation of macrophages to promote immunosuppression and wound healing. Activated IL-4 and IL-13 receptors recruit the tyrosine phosphatases SHP-1 and SHP-2, which dephosphorylate and inhibit the IL-4Rα subunit. Here, we report that the immunoreceptor SIRPα spatially restricted SHP-2 to promote IL-4 and IL-13 signaling and the alternative activation of macrophages.
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