Publications by authors named "Coralie Borne"
Haematologica
November 2023
Article Synopsis
- Chronic lymphocytic leukemia (CLL) cells rely heavily on their surrounding tumor microenvironment for growth, making it crucial to explore new treatment options that can boost the immune response.
- The study focused on interleukin 27 (IL-27), revealing that a lack of IL-27 leads to worse CLL outcomes and creates a more immunosuppressive environment in mouse models.
- IL-27 not only enhances the activation and effectiveness of CD8+ T cells against CLL in both mice and human samples, but its levels decrease during CLL progression, suggesting it could be an effective treatment option for patients.
