Publications by authors named "Cora L Bright"
Armadillo repeat-containing X-linked protein-1 (Armcx1) is a poorly characterized transmembrane protein that regulates mitochondrial transport in neurons. Its overexpression has been shown to induce neurite outgrowth in embryonic neurons and to promote retinal ganglion cell (RGC) survival and axonal regrowth in a mouse optic nerve crush model. In order to evaluate the functions of endogenous Armcx1 in vivo, we have created a conditional Armcx1 knockout mouse line in which the entire coding region of the Armcx1 gene is flanked by loxP sites.
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- Mitochondria are crucial for neuron function and must be well-distributed along axons, particularly in the glial lamina (GL) of retinal ganglion cells (RGCs).
- The GL, known for high mitochondrial density, serves as a hotspot for RGC degeneration in glaucoma, linking mitochondrial issues to this condition.
- This study challenges the belief that myelination patterns control mitochondrial accumulation, revealing instead that larger RGC axons have high mitochondrial density before myelination occurs.