Publications by authors named "Cora Bisbee"
Persistent left superior vena cava (PLSVC) draining to the left atrium (LA) is a rare congenital abnormality that is often asymptomatic and found incidentally on imaging. PLSVC is usually described alongside other congenital defects, such as septal defects, tetralogy of fallot, and aortic coarctation. PLSVC to LA with an atrial septal defect is known as Raghib syndrome, but to our knowledge PLSVC to LA without an atrial septal defect or right superior vena cava has not been described in the literature.
View Article and Find Full Text PDFThe current standard of care for pediatric patients with unrepairable congenital valvular disease is a heart valve implant. However, current heart valve implants are unable to accommodate the somatic growth of the recipient, preventing long-term clinical success in these patients. Therefore, there is an urgent need for a growing heart valve implant for children.
View Article and Find Full Text PDFMany young adults require heart valve replacements. Current options for valve replacement in adults include mechanical valves, bioprosthetic valves, or the Ross procedure. Of these, mechanical and bioprosthetic valves are the most common options, although mechanical valve usage predominates in younger adults due to durability, while bioprosthetic valve usage predominates in older adults.
View Article and Find Full Text PDFPediatric patients often undergo surgery during terminal admissions. However, the involvement and timing of palliative care consults in caring for these patients has not been readily described. To describe the presence and timing of palliative care consults for pediatric patients who undergo surgical procedures during terminal admissions.
View Article and Find Full Text PDFArticle Synopsis
- - Lung transplantation is crucial for treating severe lung disease, but there's a shortage of donors; new criteria have increased donor options but come with challenges in preparation time and preservation of donor lungs.
- - Current preservation methods like static cold storage are basic and inexpensive, but they don’t effectively reduce damage to lungs; newer technologies like ex vivo lung perfusion (EVLP) allow for better lung evaluation and preservation by keeping them ventilated and perfused.
- - While EVLP devices are more expensive and require more resources than traditional storage methods, they may improve preservation time and lung function assessment, making them beneficial for using extended criteria donors.
Background: The treatment of babies with unrepairable heart valve dysfunction remains an unsolved problem because there are no growing heart valve implants. However, orthotopic heart transplants are known to grow with recipients.
Aim: Partial heart transplantation is a new approach to delivering growing heart valve implants, which involves transplantation of the part of the heart containing the valves only.
Population pharmacokinetics of crenolanib in children and young adults with brain tumors.
Cancer Chemother Pharmacol
April 2022
Purpose: Crenolanib, an oral inhibitor of platelet-derived growth factor receptor, was evaluated to treat children and young adults with brain tumors. Crenolanib population pharmacokinetics and covariate influence were characterized in this patient population.
Methods: Patients enrolled on this phase I study (NCT01393912) received oral crenolanib once daily.