Publications by authors named "Cople-Rodrigues Claudia"
Background/objectives: Sickle cell anemia (SCA) is marked by hypoxia, inflammation, and secondary iron overload (IO), which potentially modulate hepcidin, the pivotal hormone governing iron homeostasis. The aim was to evaluate the iron incorporation in red blood cells (RBC) in SCA pediatric patients, considering the presence or absence of IO.
Subjects/methods: SCA children (n = 12; SCA) ingested an oral stable iron isotope (Fe) and iron incorporation in RBC was measured after 14 days.
Background: Herbal medicine is a low-cost treatment and has been increasingly applied in obesity treatment. Gut microbiota (GM) is strongly associated with obesity pathogenesis.
Methods: We conducted a systematic review guided by the question: "Does the use of herbal medicine change the GM composition in obese individuals?" Randomized clinical trials with obese individuals assessing the effects of herbal medicine intervention in GM were retrieved from the Medline, Embase, Scopus, Web of Science, and Cochrane Library databases, including the Cochrane Controlled Trials Register.
Chronic lower-limb ulcers (LLUs) are ulcers that fail to proceed through an orderly and timely process to produce anatomic and functional integrity. LLUs reduce the quality of life of affected individuals and are a public health problem. The treatment options include medications or surgery.
View Article and Find Full Text PDFObjective: This study evaluates the association of serum retinol, hepcidin levels, and anemia in children.
Methods: This cross-sectional study included 312 children, ages 6 to 59 mo, from Rio de Janeiro, Brazil. The association between hepcidin and retinol levels, hematologic parameters, and body mass index (BMI) was analyzed using a generalized linear model with and without adjustment for C-reactive protein (CRP) level.
Article Synopsis
- There is a lack of established dietary guidelines for diseases associated with iron overload (IOL), but hepcidin hormone plays a crucial role in regulating iron absorption.
- This scoping review explores existing studies to help develop dietary prescriptions for IOL patients, emphasizing the importance of managing iron intake.
- Certain food substances, like polyphenols and 6-shogaol, may reduce iron absorption, while vitamin C and alcohol should be avoided to prevent increased absorption and toxic reactions in those with excessive iron.
Hemolysis is one of the main pathophysiological characteristics of sickle cell disease (SCD) and might cause or could be the result of oxidative stress. Antioxidants are studied in SCD due to their potential to ensure redox balance and minimize deleterious effects on erythrocyte membranes. The objective of this systematic review was to evaluate the efficacy of antioxidant nutrient supplementation on reducing hemolysis in SCD patients through randomized clinical trials.
View Article and Find Full Text PDFLow intake of dietary fibre among Brazilian adolescents and association with nutritional status: cross-sectional analysis of Study of Cardiovascular Risks in Adolescents data.
Public Health Nutr
October 2020
Article Synopsis
- A study evaluated dietary fiber intake among Brazilian adolescents, finding the average intake was only 19.1 g/d, with just 13.1% meeting recommended levels.
- The research indicated that adolescents who were overweight or obese were significantly more likely to have inadequate fiber intake.
- The findings highlight the need for improved nutrition education policies, as fiber is crucial for preventing obesity and managing chronic diseases.
Article Synopsis
- Vitamin D is important for bone and metabolic health, yet many adolescents in Brazil suffer from low levels, or hypovitaminosis D, despite the country's sunny climate.
- The study analyzed vitamin D levels in 1,152 adolescents aged 12-17 from four Brazilian cities, revealing that 21% had levels below 20 ng/mL and 42% fell between 21 and 29 ng/mL.
- Factors contributing to low vitamin D included gender, geographic location, data collection season, non-white ethnicity, and private school attendance, with obesity being a significant risk factor for boys, while adequate dietary intake helped prevent deficiency.
Background & Aims: The nutritional status of people with human T-lymphotropic virus (HTLV-1) infection has been poorly described because it involves a neglected disease. The few studies that have been conducted mostly involve people with neurologic consequences and the possible clinical evolutions of the disease. The aim of this study was to describe the nutritional status of patients with HTLV-1, including those with associated myelopathy/tropical spastic paraparesis, and to evaluate food security in these patients.
View Article and Find Full Text PDFSickle cell disease (SCD) is a genetic hemoglobinopathy characterized by chronic hemolysis. Chronic hemolysis is promoted by increased oxidative stress. Our hypothesis was that some antioxidant micronutrients (retinol, tocopherol, selenium, and zinc) would be determinant factors of the degree of hemolysis in SCD patients.
View Article and Find Full Text PDFChildren with sickle cell anemia (SCA) often exhibit nutritional deficiencies and are at high risk of dying before the age of 5 years. Ensuring adequate nutrition is a critical part of health care for such children. This study aimed to investigate the association between nutritional status, nutrient intake, and food diversity in children with SCA.
View Article and Find Full Text PDFObjective: To examine the associations between food insecurity (IA) and social support in families of children with sickle-cell disease (DF).
Methods: This cross-sectional study in families of 190 children from five to nine years old in follow-up at a hematology referral hospital in Rio de Janeiro State. IA was measured using the Brazilian food insecurity scale and social support was measured using the Brazilian version of the MOS social support survey instrument.