Integrating Patient Priorities with Science by Community Engagement in the Kidney Precision Medicine Project.

The Kidney Precision Medicine Project (KPMP) is a multisite study designed to improve understanding of CKD attributed to diabetes or hypertension and AKI by performing protocol-driven kidney biopsies. Study participants and their kidney tissue samples undergo state-of-the-art deep phenotyping using advanced molecular, imaging, and data analytical methods. Few patients participate in research design or concepts for discovery science.

Recovery in context: Sober living houses and the ecology of recovery.

Sober living houses (SLHs) are an increasingly common element of the recovery support services landscape, yet little is known about their neighborhood context. This study describes neighborhoods in which SLHs are located and examines differences by house characteristics. SLHs in Los Angeles County (N = 297) were geocoded and linked with U.

A decade of hospital-based violence intervention: Benefits and shortcomings.

Introduction: Initial analyses of hospital-based violence intervention programs (VIPs) have demonstrated decreased violent injury recidivism. Long-term VIP performance has not been assessed. Violence intervention program quality improvement requires evaluation to identify shortcomings and client subpopulations warranting additional resources.

Using iPSC-derived human DA neurons from opioid-dependent subjects to study dopamine dynamics.

Introduction: The dopaminergic (DA) system plays important roles in addiction. However, human DA neurons from drug-dependent subjects were not available for study until recent development in inducible pluripotent stem cells (iPSCs) technology.

Methods: In this study, we produced DA neurons differentiated using iPSCs derived from opioid-dependent and control subjects carrying different 3' VNTR (variable number tandem repeat) polymorphism in the human dopamine transporter (DAT or SLC6A3).

Instructional design for online course development.

There is a big difference between preparing to teach in the classroom and preparing to teach online. The classroom environment is typically marked by a level of spontaneity in instruction; beyond the preparation-the course syllabus and the PowerPoint slides, for example-the delivery of the course is largely altered by both the dynamics of the class and the impromptu decisions of the professor. Mediating this dynamic is the nature of the subject matter itself-teaching a course in computer programming varies dramatically from a course in sociology.

Association of the HLA-DR2/DR4 phenotype with skin test responses to bovine dermal collagen: a potential interaction of two MHC alleles in regulating an immune response.

We examined the HLA-DR characteristics of a population of 30 healthy collagen responders. Each had previously exhibited a localized hypersensitivity response to an intradermal challenge with a bovine collagen implant. A one-tailed binomial test revealed a significant increase in the alloantigen DR2 (p less than 0.

Collagen implantation in patients treated previously with silicone.

This multicentric, open study evaluated the efficacy and safety of Zyderm Collagen Implant (ZCI) in 158 patients with contour deficiencies of the dermis and a history of silicone fluid therapy. Following test implantation with ZCI, thirty-seven patients dropped out, including four patients who exhibited untoward responses to the implant material. Hence, 121 patients completed the course of therapy and were available for efficacy and safety evaluation.

Injectable collagen: a six-year clinical investigation.

An injectable form of bovine dermal collagen has been developed for use in correcting cutaneous contour deficiencies. This material is a sterile device composed predominantly of highly purified type I collagen dispersed in phosphate-buffered physiological saline containing 0.3% lidocaine.

The immunogenicity of injectable collagen. II. A retrospective review of seventy-two tested and treated patients.

Sera were collected from seventy-two patients who had been exposed to a preparation of a bovine collagen implant in widespread clinical use for correction of dermal defects ( Zyderm Collagen Implant [hereafter referred to as "the implant"]; Collagen Corporation, Palo Alto, CA). Thirty-one of these patients had reported implant site reactions alone, thirty-five had reported generalized symptoms without implant site involvement, and six had reported implant site reactions accompanied by generalized symptoms. Results of a radioimmunoassay performed on these sera showed that elevated levels of anti-implant antibodies correlated significantly with localized responses at injection sites.

The immunogenicity of injectable collagen. I. A 1-year prospective study.

With the growing use of collagen-based biomaterials, questions have been raised regarding the immunogenicity of this protein in humans. Currently a bovine collagen implant is in widespread use for the correction of dermal contour deficiencies ( Zyderm Collagen Implant (hereafter referred to as "the implant"); Collagen Corporation, Palo Alto, CA). To investigate potential immunologic consequences of this material, sixty-one subjects were evaluated in a 1-year prospective study.

Carcinoma of urachus with extensive abdominal calcification.

Carcinoma of the urachus, a relatively rare genitourinary neoplasm, usually presents as a supravesical mass. This tumor may occasionally calcify, which together with other radiographic and clinical features may permit a specific preoperative diagnosis. The calcifications also enable an evaluation of recurrence via plain films.

Computerized radiographic reporting in a community hospital: a consumer's report.

This report analyzes a 30 month experience with a commerically available mark sense form-based automated radiographic reporting system (RAPORT) in the diagnostic radiology department of a 400 bed general hospital. By using the system, five radiologists were able to completely formulate readable diagnostic radiology reports in 65% of all cases, thereby bypassing a transcriptionist and decreasing report turnaround time dramatically without sacrificing reporting time. Moreover, billing and statistical capabilities provided by the system were found to capture enough lost charges to pay for its entire cost.

Delayed opacification in congenital multicystic dysplastic kidney, an important Roentgen sign.

Two cases of delayed opacification of multiple irregular cystic spaces are reported in unilateral congenital multicystic kidney. This finding should be added to the basic excretory urographic sings of poor function, cystic spaces on total body opacification, and calyceal crescents, and indicates the need for delayed films in all such cases. Reevaluation of the necessity for further diagnostic study and nephrectomy are discussed.

Regional myocardial function in idiopathic hypertrophic subaortic stenosis. An echocardiographic study.

To assess regional contractility in idiopathic hypertrophic subaortic stenosis (IHSS), a primary myopathic disorder with documented hyperdynamic ventricular contractions, systolic wall thickening and velocity of contraction of the septum and left ventricular posterior wall were measured in echocardiograms from 16 patients with IHSS and 16 normal subjects. The average thickening of the normal septum and posterior wall was 75.9+/-8.

Xeromammography in the early detection of breast cancer. Community hospital experience and approach.

Community hospitals can do much in the general effort toward earlier detection of breast cancer. Using xeromammography in the department of general radiology of one community hospital, 21 cases of occult carcinoma were detected in 2,392 patients in a two year period. Patients were both symptomatic and asymptomatic.

Effects of anesthetics on splanchnic circulation and metabolism.

In the last 10 years intense interest in "halothane hepatitis" plus simpler and more reliable technology for measuring splanchnic blood flow have led to a fuller understanding of the splanchnic effects of anesthetics. For the first time, a rational choice of anesthetic technique can be made for the patient with splanchnic organ dysfunction.

Vesiculographic findings in cysts of the seminal vesicle.

Vasoseminal vesiculography showed medial displacement and stretching of the ampulla of the vas deferens in 3 patients with cysts of the seminal vesicle. In 2 a nonopacified mass separated the ampulla from the ipsilateral seminal vesicle. All 3 patients were managed without surgical intervention.

Hypertension in the immediate postoperative period.

Sixty patients out of 1,844 recovery room admissions had significant postoperative arterial hypertension. Nearly 60% of them had a history of hypertension. The postoperative hypertension usually began within 30 min from the end of operation and lasted about 2 hours.