Publications by authors named "Cooper Quartermaine"
Article Synopsis
- Hematopoietic stem cell transplantation (HSCT) can treat various serious blood disorders but increases the risk of cardiovascular issues, particularly for patients undergoing allogeneic transplantation compared to autologous.
- A study analyzed data from the National Inpatient Sample (2016-2019) to compare the rates of atrial fibrillation (AF) and major adverse cardiac events (MACE) between the two transplantation types.
- Findings revealed that allogeneic HSCT patients have significantly higher odds of experiencing serious heart problems and mortality during hospitalization, with AF being a key predictor of poor outcomes.
Article Synopsis
- The treatment of chronic lymphocytic leukemia (CLL) has evolved from traditional chemotherapy to modern targeted therapies, particularly Bruton's tyrosine kinase (BTK) inhibitors, which have significantly changed patient outcomes.
- Despite their effectiveness, the first BTK inhibitor, ibrutinib, is linked to serious cardiovascular side effects, affecting a substantial number of patients with conditions like atrial fibrillation and ventricular arrhythmias.
- The review discusses the evidence around these toxicities, including risk factors and management strategies, while also highlighting the potential of newer BTK inhibitors and the need for further research into unresolved questions in the field.
Purpose Of Review: As the percentage of patients achieving long-term survival following treatment of their cancer grows, it is increasingly important to understand the long-term toxicities of cancer-directed treatment. In this review, we highlight the recent findings regarding radiation-induced cardiotoxicity across multiple disease sites, with a particular focus on heart failure.
Recent Findings: Despite its relative lack of study historically, radiation-induced heart failure has now recently been implicated in several studies of breast cancer, lung cancer, esophageal cancer, and lymphoma as a non-trivial potential consequence of thoracic radiotherapy.