Design of a new Ni@NCNT/graphene hybrid structured catalyst for high-performance electrochemical CO reduction: unravelling the roles of N-doping.

Doping strategies have been recognized as effective approaches for developing cost-effective and durable catalysts with enhanced reactivity and selectivity in the electrochemical synthesis of value-added compounds directly from CO. However, the reaction mechanism and the specific roles of heteroatom doping, such as N doping, in advancing the CO reduction reaction are still controversial due to the lack of precise control of catalyst surface microenvironments. In this study, we investigated the effects of N doping on the performances for electrochemically converting CO to CO over Ni@NCNT/graphene hybrid structured catalysts (Ni@NCNT/Gr).

A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides.

Mitotic activity is an important feature for grading several cancer types. However, counting mitotic figures (cells in division) is a time-consuming and laborious task prone to inter-observer variation. Inaccurate recognition of MFs can lead to incorrect grading and hence potential suboptimal treatment.

A Comprehensive Proteomic and Bioinformatic Analysis of Human Spinal Cord Injury Plasma Identifies Proteins Associated with the Complement Cascade and Liver Function as Potential Prognostic Indicators of Neurological Outcome.

Spinal cord injury (SCI) is a major cause of disability, with complications postinjury often leading to lifelong health issues with the need for extensive treatment. Neurological outcome post-SCI can be variable and difficult to predict, particularly in incompletely injured patients. The identification of specific SCI biomarkers in blood may be able to improve prognostics in the field.

Au@TiO Core-Shell Nanoparticles with Nanometer-Controlled Shell Thickness for Balancing Stability and Field Enhancement in Plasmon-Enhanced Photocatalysis.

Plasmonic core-shell nanostructures can make photocatalysis more efficient for several reasons. The shell imparts stability to the nanoparticles, light absorption is expanded, and electron-hole pairs can be separated more effectively, thus reducing recombination losses. The synthesis of metal@TiO core-shell nanoparticles with nanometer control over the shell thickness and understanding its effect on the resulting photocatalytic efficiency still remains challenging.

Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model.

Objective: To determine if mesenchymal stromal cells (MSCs) derived from human umbilical cords (hUC) could reduce degeneration developing when injected into the knee of a large animal model of osteoarthritis (OA).

Design: Ten million culture-expanded UC-MSCs (pooled from 3 human donors) were injected in 50 μL of tissue culture medium into the left stifle joints of 7 sheep whose medial meniscus was transected 4 weeks previously. Seven other sheep had only 50 μL of medium injected as the no treatment "control" group.

Surface modification of mesostructured cellular foam to enhance hydrogen storage in binary THF/H clathrate hydrate.

This study introduces solid-state tuning of a mesostructured cellular foam (MCF) to enhance hydrogen (H) storage in clathrate hydrates. Grafting of promoter-like molecules (, tetrahydrofuran) at the internal surface of the MCF resulted in a substantial improvement in the kinetics of formation of binary H-THF clathrate hydrate. Identification of the confined hydrate as sII clathrate hydrate and enclathration of H in its small cages was performed using XRD and high-pressure H NMR spectroscopy respectively.

Tailored Covalent Organic Framework Platform: From Multistimuli, Targeted Dual Drug Delivery by Architecturally Engineering to Enhance Photothermal Tumor Therapy.

Engineering bulk covalent organic frameworks (COFs) to access specific morphological structures holds paramount significance in boosting their functions in cancer treatment; nevertheless, scant effort has been dedicated to exploring this realm. Herein, silica core-shell templates and multifunctional COF-based reticulated hollow nanospheres (HCOFs) are novelly designed as a versatile nanoplatform to investigate the simultaneous effect of dual-drug chemotherapy and photothermal ablation. Taking advantage of the distinct structural properties of the template, the resulting two-dimensional (2D) HCOF, featuring large internal voids and a peripheral interconnected mesoporous shell, presents intriguing benefits over its bulk counterparts for cancer treatment, including a well-defined morphology, an outstanding drug loading capability (99.

Using nanopore sequencing to identify bacterial infection in joint replacements: a preliminary study.

This project investigates if third-generation genomic sequencing can be used to identify the species of bacteria causing prosthetic joint infections (PJIs) at the time of revision surgery. Samples of prosthetic fluid were taken during revision surgery from patients with known PJIs. Samples from revision surgeries from non-infected patients acted as negative controls.

Aneurysmal bone cysts: A UK wide tumor center experience.

Background And Objectives: This multicenter retrospective series of consecutive extra-spinal aneurysmal bone cysts aims to identify risk factors for treatment failure.

Methods: Aneurysmal bone cysts treated within seven collaborating centers with over 12-months follow-up were eligible for inclusion. Survival analyses were performed to identify variables associated with recurrence using log-rank tests and Cox proportional hazard regression.

The British Orthopaedic Oncology Management (BOOM) audit.

Aims: Most patients with advanced malignancy suffer bone metastases, which pose a significant challenge to orthopaedic services and burden to the health economy. This study aimed to assess adherence to the British Orthopaedic Oncology Society (BOOS)/British Orthopaedic Association (BOA) guidelines on patients with metastatic bone disease (MBD) in the UK.

Methods: A prospective, multicentre, national collaborative audit was designed and delivered by a trainee-led collaborative group.

Clinical outcome of open ankle fractures in patients above 70 years of age.

Background: Open fractures of the ankle are complex injuries requiring multidisciplinary input and are associated with significant morbidity and mortality. However, data on the clinical outcomes of open ankle fracture management in patients older than 70 is minimal.

Aim: To evaluate the clinical outcomes following open ankle fracture management in patients older than 70.

Structured LDH/Bentonite Composites for Chromium Removal and Recovery from Aqueous Solutions.

This study focuses on chromium removal through adsorption and ion exchange using structured calcined layered double hydroxide (LDH) (MgAl)-bentonite composites. Firstly, the powders were structured into granulates to study the effect on Cr sorption kinetics to circumvent the limitations of working with powders in real-life applications. Secondly, the regeneration of the structured composites was optimized to enable multi-cycling operation, which is the key for their applicability beyond laboratory scale.

Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report.

There is currently no "gold-standard" method to diagnose prosthetic joint infections (PJI), and the current practice of using microbiological cultures has many limitations. The identification of the bacterial species causing the infection is crucial to guide treatment; therefore, a robust method needs to be developed. Here, we attempt to use genomic sequencing with the MinION device from Oxford Nanopore Technologies to identify the species of bacteria causing PJI in a 61-year-old male.

Recent Trends in Plasmon-Assisted Photocatalytic CO Reduction.

Direct photocatalytic reduction of CO has become an highly active field of research. It is thus of utmost importance to maintain an overview of the various materials used to sustain this process, find common trends, and, in this way, eventually improve the current conversions and selectivities. In particular, CO photoreduction using plasmonic photocatalysts under solar light has gained tremendous attention, and a wide variety of materials has been developed to reduce CO towards more practical gases or liquid fuels (CH , CO, CH OH/CH CH OH) in this manner.

Sunlight-Powered Reverse Water Gas Shift Reaction Catalysed by Plasmonic Au/TiO Nanocatalysts: Effects of Au Particle Size on the Activity and Selectivity.

This study reports the low temperature and low pressure conversion (up to 160 °C, = 3.5 bar) of CO and H to CO using plasmonic Au/TiO nanocatalysts and mildly concentrated artificial sunlight as the sole energy source (up to 13.9 kW·m = 13.

A genetic model for central chondrosarcoma evolution correlates with patient outcome.

Background: Central conventional chondrosarcoma (CS) is the most common subtype of primary malignant bone tumour in adults. Treatment options are usually limited to surgery, and prognosis is challenging. These tumours are characterised by the presence and absence of IDH1 and IDH2 mutations, and recently, TERT promoter alterations have been reported in around 20% of cases.

Mirels' score for upper limb metastatic lesions: do we need a different cutoff for recommending prophylactic fixation?

Hypothesis: The aim of this study was to investigate the reproducibility, reliability, and accuracy of Mirels' score in upper limb bony metastatic disease and validate its use in predicting pathologic fractures.

Methods: Forty-five patients with upper limb bony metastases met the inclusion criteria (62% male 28/45). The mean age was 69 years (SD 9.

A Rare Presentation of a Solitary Melanoma Bone Metastasis.

A 74-year-old woman presented with sudden onset pain and swelling in her right wrist. Plain radiographs showed a pathological fracture through a lytic lesion. The patient had a past medical history of melanoma on her right thigh, which had been excised two years previously.

Joint replacement surgery for elbow tumours: a systematic review of outcomes.

Background: Tumour resection followed by joint reconstruction is a surgical option in the appropriate patient. The evidence for such reconstructive surgery of the elbow joint is limited. The aim of this study is to review the literature to evaluate the outcomes of joint replacement surgery in tumours of the elbow.