Publications by authors named "Consuelo Gonzalez"
Article Synopsis
- Missing self-recognition in cancer makes it vulnerable to natural killer cells (NKc), yet this model overlooks the role of inhibitory receptors (iKIR) that enhance NKc reactivity by binding to specific HLA-I ligands.
- A study involving 164 myeloma patients and 286 controls revealed that myeloma patients exhibited higher frequencies of certain KIR genotypes and less diverse NKc repertoires, which correlated with increased susceptibility to the disease.
- Myeloma cells displayed over-expression of HLA-I, suggesting a unique interaction with licensed NKc that might lead to more effective immune responses against these cells, particularly in cases lacking conventional iKIR2D/HLA-C interactions.
Background: The purpose of this study is to better characterize the hematological, biochemical, respiratory, cardiovascular and electroneurophysiological parameters in young adult Cercopithecus aethiops sabaeus of both sexes. The rhesus and cynomolgus monkeys are widely used as experimental primate models. However, only few articles have been published testing toxicological effects of pharmaceuticals on African green monkey.
View Article and Find Full Text PDFObjective: To evaluate the in vivo antimicrobial activity of different forms of application of chlorhexidine digluconate (CHX).
Method And Materials: A group of 10 volunteers performed mouth rinsings with a 0.2% and 0.
Nimotuzumab (h-R3) is a humanized anti-epidermal growth factor receptor monoclonal antibody (mAb) registered for treating head and neck tumours. The present study was designed to evaluate the systemic and skin toxicity of chronic intravenous administration of the h-R3 in a relevant species demonstrated by comparing the h-R3 binding affinity constants (Kd) in microsomal placental fractions from Homo sapiens and Cercopithecus aethiops monkeys using an EGF-Receptor radioligand competition assay. The Kd obtained for Nimotuzumab were 9.
View Article and Find Full Text PDFThis study aimed at characterising the distribution of human leucocyte antigen (HLA)-C alleles in a large group of patients with B chronic lymphocytic leukaemia from Southeastern Spain. Ninety-eight adult patients and 194 geographically and ethnically matched controls were studied. HLA-C was determined by polymerase chain reaction sequence-specific primers (PCR-SSP) and PCR-sequence-specific oligonucleotides (SSO) methods.
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