Effect of different biomaterials on the expression pattern of the transcription factor Ets2 in bone-like constructs.

Tissue engineering offers an exciting prospect for reconstructive surgery by replacing missing natural scaffolds with artificial ones. For optimal success the artificial scaffold should provide an environment closely resembling the natural tissue. Little is known about the direct influence of the scaffold on the expression of regulators of bone development, such as transcription factors.

Phenothiazine chloride and soft laser light have a biostimulatory effect on human osteoblastic cells.

Objective: Low-level laser therapy (LLLT) is a well accepted tool to accelerate wound healing and to reduce inflammation after oral implant insertion. Since there are no in vitro data on a combination of LLLT with prior photosensitization, it was the aim of this study to investigate if photosensitization with phenothiazine chloride results in an alteration of the biostimulatory effect of low-level laser irradiation.

Background Data: LLLT and antimicrobial photodynamic therapy are well established for the treatment of peri-implantitis.