Publications by authors named "Constanze Mueller"

Complex mixtures containing natural products are still an interesting source of novel drug candidates. High content screening (HCS) is a popular tool to screen for such. In particular, multiplexed HCS assays promise comprehensive bioactivity profiles, but generate also high amounts of data.

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Atopic eczema (AE) is an inflammatory skin disorder affecting approximately 20% of children worldwide and early onset can lead to asthma and allergies. Currently, the mechanisms of the disease are not fully understood. Metabolomics, the analysis of small molecules in the skin produced by the host and microbes, opens a window to observe the mechanisms of the disease which then may lead to new drug targets for AE treatment.

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Article Synopsis
  • - Type 2 diabetes mellitus (T2DM) is a significant public health challenge, prompting exploration of current and future drug options and research methods.
  • - The review highlights the potential of image-based high-content screening (HCS) when combined with metabolomics or lipidomics to improve drug testing by analyzing small molecule effects on cells.
  • - The integration of these advanced technologies with artificial intelligence enhances the ability to analyze complex data, allowing for better understanding of cellular responses and drug interactions related to T2DM.
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Ferroptosis is an iron-dependent form of cell death driven by biochemical processes that promote oxidation within the lipid compartment. Calcium (Ca) is a signaling molecule in diverse cellular processes such as migration, neurotransmission, and cell death. Here, we uncover a crucial link between ferroptosis and Ca through the identification of the novel tetraspanin MS4A15.

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Our skin influences our physical and mental health, and its chemical composition can reflect environmental and disease conditions. Therefore, through sampling the skin metabolome, we can provide a promising window into the mechanisms of the body. However, the broad application of skin metabolomics has recently been hampered by a lack of easy and widely applicable sampling methods.

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Background: Common ragweed has been spreading as a neophyte in Europe. Elevated CO levels, a hallmark of global climate change, have been shown to increase ragweed pollen production, but their effects on pollen allergenicity remain to be elucidated.

Methods: Ragweed was grown in climate-controlled chambers under normal (380 ppm, control) or elevated (700 ppm, based on RCP4.

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Purpose: To assess surface characteristics and implant stability after implantoplasty performed by two different instrument sequences regarding material loss, surface roughness, and fracture load resistance. Additionally, operators' subjective experience during instrumentation and the damage to neighboring teeth were evaluated.

Materials And Methods: Titanium implants were placed in the position of both first maxillary molars in models exposing 6 mm of their surface.

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Background: Alumina-toughened zirconia (ATZ) is a possible alternative material to titanium for oral implants. No data are available on the fracture strength of ATZ oral implants.

Purpose: The purpose of this study was to examine one-piece implants made of ATZ ceramic under artificial loading conditions and to compare the fracture strength of these implants with implants fabricated from tetragonal zirconium dioxide poylcrystal (TZP)-A.

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