Publications by authors named "Constanza Jackson"
Article Synopsis
- The Xist long noncoding RNA plays a key role in X chromosome inactivation, involving the silencing of genes and changes to the chromosome's 3D structure.
- Xist interacts with the Lamin B receptor, which is crucial for linking the inactive X chromosome to the nuclear lamina, thereby facilitating gene silencing.
- The study confirms that this interaction alters the 3D arrangement of DNA, allowing Xist and its associated proteins to effectively spread and silence genes across the X chromosome.
The long non-coding RNA X-inactive specific transcript (XIST) mediates the transcriptional silencing of genes on the X chromosome. Here we show that, in human cells, XIST is highly methylated with at least 78 N-methyladenosine (mA) residues-a reversible base modification of unknown function in long non-coding RNAs. We show that mA formation in XIST, as well as in cellular mRNAs, is mediated by RNA-binding motif protein 15 (RBM15) and its paralogue RBM15B, which bind the mA-methylation complex and recruit it to specific sites in RNA.
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