Publications by authors named "Constantinos I Pantos"

Background: Thyroid hormone (TH) appears to have a reparative action on the postinfarcted myocardium. This novel action was recently tested in a pilot, randomized, double-blind, placebo-controlled trial (ThyRepair). The present study performed a analysis of data from the ThyRepair study to provide further insights into the novel actions of TH on the human postischemic myocardium.

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Thyroid hormone has a differential action on healthy and ischemic heart. Triiodothyronine (T3) administration improved postischemic cardiac function while it limited apoptosis in experimentally induced ischemia. Thus, the present study investigated the potential effects of acute liothyronine (LT3) treatment in patients with anterior myocardial infarction.

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Article Synopsis
  • Tissue hypoxia can occur due to conditions like heart attacks, brain ischemia, sepsis, and trauma, leading to cell damage and organ failure through a process that resembles fetal development.
  • There is a connection between damaged hypoxic organs and developing organs, suggesting that the same regulatory networks driving embryonic development might also assist in tissue repair.
  • Thyroid hormone (TH) plays a crucial role in organ development and may help manage hypoxia by preventing remodeling after heart injuries and early tissue damage during sepsis, potentially reducing the risk of secondary organ failure.
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We have previously shown that long-term thyroxine administration can protect the heart against ischemia. In the present study, we investigated whether thyroxine-induced cardioprotection can mimic the pattern of protection that is afforded by a well-established cardioprotective means such as ischemic preconditioning. In a Langendorff-perfused rat heart preparation, after an initial stabilization, normal and thyroxine-treated hearts were subjected to 20 minutes of zero-flow global ischemia followed by 45 minutes of reperfusion.

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