Publications by authors named "Constantinoiu S"

Muscle-invasive bladder tumors (MIBT) usually require radical cystectomy (RC) followed by urinary diversion to maintain urinary flow. The two main methods used are simple direct cutaneous ureterostomy (SDCU) and Bricker ileal conduit diversion (BICD), each with distinct advantages and disadvantages. This study compares the outcomes of these two techniques across two university centers in Romania, with each center employing a different surgical approach Material and A retrospective study was conducted on 64 patients with MIBT, divided into two equal groups.

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Background: Chronic inflammation is associated with different cancers, and is identified as a key pathogenic mechanism in ovarian cancer. The purpose of our study was to evaluate systemic inflammation markers, as predictive and prognostic factors, in ovarian cancer patients with initial surgical treatment.

Subjects And Methods: We performed a retrospective study on 60 ovarian cancer patients with primary cytoreduction surgery, between 2010-2018, with a follow-up period of at least one year.

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Caustic ingestion remains a complex public health problem worldwide, both in adults and children. The consequences of caustic ingestion depend on the severity of the injuries, the general condition of the patient at presentation and the promptness of medical management. Long-term complications include strictures or stenoses, resulting in dysphagia.

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Article Synopsis
  • Esophageal anastomotic fistula (AF) is a common and serious complication after esophagectomy for cancer, typically managed with endoscopic stents.
  • A study analyzed data from 55 patients with AF to investigate healing times and factors affecting them, focusing on hospital stays and stent usage until the fistula closed.
  • Findings revealed that different anastomosis types affected healing durations, with eso-gastric anastomosis patients experiencing longer hospital stays and eso-gastric cervical anastomosis showing prolonged fistula closure, particularly influenced by fistula size and prior radiotherapy treatments.
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This study investigates the correlation between the histopathologically confirmed or refuted diagnosis of Hirschsprung Disease (HD) and the type of surgery performed on patients. Data from 24 patients were analyzed, divided into two categories: confirmed HD (n=17) and refuted HD (n=7). The results did not identify a statistically significant association between the diagnosis of HD and the sex of the patients (p-value = 1.

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Article Synopsis
  • Hirschsprung's disease is a condition babies can be born with where certain nerve cells are missing from the intestines, causing problems with digestion and constipation.
  • It happens in about 1 in 5,000 newborns and is more common in boys.
  • Treatment usually involves surgery to remove the part of the intestine that doesn't work right, with special care after surgery to help kids get better and live healthier lives.
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Achalasia is the most well-known motility disorder, characterized by the lack of optimal relaxation of the lower esophageal sphincter during swallowing and the absence of peristalsis of the esophageal body. Laparoscopic Heller esocardiomyotomy (LHM) and pneumatic dilation (PD) were the main treatment options for achalasia. Currently, the therapeutic methods are complemented by per-oral endoscopic myotomy (POEM).

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Minimally invasive surgery is increasingly indicated in the management of malignant disease. Although oesophagectomy is a difficult operation, with a long learning curve, there is actually a shift towards the laparoscopic/thoracoscopic/ robotic approach, due to the advantages of visualization, surgeon comfort (robotic surgery) and the possibility of the whole team to see the operation as well as and the operating surgeon. Although currently there are still many controversial topics, about the surgical treatment of patients with gastro-oesophageal junction (GOJ) adenocarcinoma, such as the type of open or minimally invasive surgical approach, the type of oesophago-gastric resection, the type of lymph node dissection and others, the minimally invasive approach has proven to be a way to reduce postoperative complications of resection, especially by decreasing pulmonary complications.

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At the level of the genital system, ovarian neoplasm is the most frequent cause of morbidity and mortality. In the specialized literature, the coexistence of an inflammatory process is admitted from the early stages of the evolution of this pathology. Starting from the importance of this process, both in determinism and in the evolution of carcinogenesis and summarizing the field of knowledge, for this study we considered two objectives: the first was the presentation of the pathogenic mechanism, through which chronic +ovarian inflammation is involved in the process of carcinogenesis, and the second is the justification of the clinical utility of the three parameters, accepted as biomarkers of systemic inflammation: neutrophil-lymphocyte ratio, platelet lymphocyte ratio, and lymphocyte-monocyte ratio in the assessment of prognosis.

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Unlabelled: Esophageal fistula remains one of the main postoperative complications, with the treatment often requiring the use of stents. This article reviews the updates on the use of endoscopic stents for the treatment of postoperative esophageal leakage in terms of indications, types of stents used, efficiency, specific complications and perspectives.

Materials And Methods: We searched the PubMed and MEDLINE databases for the keywords postoperative esophageal anastomotic leak and postoperative esophageal anastomotic leak stent, and retrieved relevant papers published until December 2022.

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Background And Objective: Esophageal diverticulum (ED) is a relatively rare condition, characterized by high etio- and pathophysiological versatility, with an uncommon clinical impact, consequently requiring a complete and complex diagnostic evaluation, so that the therapeutic decision is "appropriate" to a specific case. The aim of the paper is, therefore, a reassessment of the diagnostic possibilities underlying the establishment of the therapeutic protocol and the available therapeutic resources, making a review of the literature, and a non-statistical retrospective analysis of cases hospitalized and operated in a tertiary center.

Methods: Thus, classical investigations (upper digestive endoscopy, barium swallow) need to be correlated with complex, manometric, and imaging evaluations with direct implications in therapeutic management.

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Background: Mucosal perforation during laparoscopic esocardiomyotomy is quite frequent, and its consequences cannot always be neglected. The purpose of the study is to investigate the risk factors for intraoperative mucosal perforation and its implications on the postoperative outcomes and the functional results three months postoperatively.

Material And Methods: We retrospectively identified the patients with laparoscopic esocardiomyotomy performed at Sf.

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Article Synopsis
  • Chylothorax is a rare but serious complication that can occur after esophageal cancer surgery, particularly during the esophagectomy phase.
  • Management typically starts with conservative treatment, but surgical options like thoracic duct ligation may be necessary for persistent cases.
  • There is no clear consensus on management due to its rarity, but a minimally invasive thoracoscopic approach has been successfully used in some cases, and vigilance for potential thoracic duct injury is crucial post-surgery.
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Malignant extramucosal esophageal tumors are rare. We publish a case of an extramucosal esophageal tumor which turned out to be a yolk sac tumor. This type of tumor is extremely rare.

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Achalasia is a motility disorder characterized by the absence of optimal relaxation of the lower esophageal sphincter (LES) with swallowing and lack of peristalsis of the esophageal body. Excepting temporary medical options, the treatment aims to lower the LES pressure by endoscopic or surgical means. Either method involves a risk of perforation.

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Anastomotic fistulas after surgery for esophageal cancer, remain a challenge for both the surgeon and the gastroenterologist. The aim of the study is to highlight the role of esophageal stenting in the management of leaks after esophagectomy for malignancies. We reviewed the available literature on the endoscopic treatment of esophageal anastomotic leaks, especially articles on endoscopic stenting in the management of this complication.

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Regardless of the reconstruction surgery used, the fundamental concepts of visceral reconstruction are based on the vascular support needed for the substituting graft. The vascular factor is the main element of any reconstruction technique, as an underlying condition for the visceral material stretch and, along with other factor, for the suture safety. In the case of the stomach, a consistent vascular flow and the minimal vascular anatomy variations are the first theoretical argument.

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I would begin this history with a brief but eloquent statement made by professor Teodor Horvat, PhD (one, if not the most important, of the "rescuers" of modern thoracic surgery in our country) in the successful preface of the "Treaty of Pathology and Esophageal Surgery" (Romanian Academy Publishing House, Bucharest, 2017): "The esophagus passes through our territory the thorax!" It is an undeniable truth, but so is the extremely small number of thoracic surgeons with expertise in esophageal surgery. Unfortunately, they are very scarce. They are thoracic surgeons who have specialized in thoracic surgery starting from general surgery.

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Breast cancer is one of the most severe health issues globally, but the therapy advancements and the constant adaptation of treatment protocols radically changed its prognoses. This article review of the literature from a surgical perspective, thus allowing for the optimum detection and placement of its role and benefits in the surgical and oncology therapeutics. The role of surgery becomes controversial, with sometimes "pretentious" techniques, hard to quantify benefits and challenges that require a thorough assessment prior to opting for surgery.

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Article Synopsis
  • Reflux disease is prevalent globally, with ongoing debates about its mechanisms and symptoms.
  • Recent advancements in technology, such as high-resolution manometry and pH impedance, are enhancing our understanding of the disease.
  • Newer treatment options are emerging that offer less invasive alternatives for patients needing more than lifestyle modifications and proton-pump inhibitors (PPIs).
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Colorectal cancer (CRC) is one of the most common human malignancies, affecting one of 20 persons in areas with high socio-economic standard but cases of digestive cancers during pregnancy are rare. From an etiological point of view, CRC represents an entity induced on the one hand by environmental factors and on the other hand by genetic factors or, not rarely, by their combination. The difficulty of diagnosing digestive cancers in pregnancy is the consequence of a symptomatology often masked by signs and symptoms that can be attributed to pregnancy.

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The emergency surgery for colorectal cancer is associated with high rates of morbidity and mortality due to factors related to the characteristics of the patients but also the therapeutic attitude. This study aims to identify the surgical interventions associated with the postoperative complications, with the main causes of morbidity, with the reinterventions and with the postoperative deaths. We included in this retrospective study 431 patients hospitalized and operated in an emergency for complicated colorectal malignant tumors in the Surgery II Clinic of the Clinical Emergency County Hospital "Sf.

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Article Synopsis
  • Ovarian cancer is a highly deadly disease, particularly diagnosed in advanced stages (III and IV), leading to low 5-year survival rates of under 45%.
  • A study analyzed 65 patients with advanced ovarian cancer over a follow-up of at least one year, assessing the correlation between survival and various clinical, tumor, and treatment characteristics.
  • The findings indicated that factors such as pelvic pain, stage at diagnosis, surgical outcomes, postoperative complications, and adjuvant treatments significantly influence overall survival, with specific treatments and surgical success acting as independent protective factors.
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The inflammatory response plays a critical role in carcinogenesis. There are recent scores based on the systemic inflammatory response, such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR), which have been shown to have prognostic value in cancer patients. These scores allow the identification of patients who will have poor response to treatment and poor survival.

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Article Synopsis
  • * A retrospective analysis of 431 patients (from 2008-2017) aimed to identify key prognostic factors by correlating clinical features, tumor characteristics, and treatment approaches with overall survival outcomes.
  • * Significant associations were found in survival rates related to various factors, including age, pre-existing health conditions, tumor characteristics, and surgical interventions, emphasizing the complexity of managing colorectal cancers in emergency settings.
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