A prospective longitudinal study of Pasireotide in Nelson's syndrome.

Purpose: Nelson's syndrome is a challenging condition that can develop following bilateral adrenalectomy for Cushing's disease, with high circulating ACTH levels, pigmentation and an invasive pituitary tumor. There is no established medical therapy. The aim of the study was to assess the effects of pasireotide on plasma ACTH and tumor volume in Nelson's syndrome.

Procalcitonin: A New Biomarker for Medullary Thyroid Cancer? A Systematic Review.

Medullary thyroid cancer (MTC) is a rare but aggressive thyroid malignancy. The gold-standard biomarker for its diagnosis and follow-up is calcitonin (CT); however, it has a variable half-life dependent on its circadian variability. It has been suggested that a more stable hormone, procalcitonin (PCT), may overcome these problems and its introduction to routine practice may give more accurate results in the diagnosis and follow-up of MTC.

Assessing the impact older people from care homes place on the emergency services.

Objective: The increasing size of our older population will provide more pressure to UK emergency services. Studies show that older people are more likely to be admitted from the emergency department (ED). This study aimed to evaluate the impact care home (CH) patients have on the ED within a large urban UK city and whether end-of-life planning and alternative pathways can improve quality of care for these patients.