Pisachini planthoppers of Vietnam: new records of and a new species from Central Vietnam (Hemiptera, Fulgoromorpha, Nogodinidae).

Two planthopper species of the family Nogodinidae are added to the fauna of Vietnam, both from two localities in Thua Thien-Hue Province: Bach Ma National Park and Phong Dien District. The first species belongs to Meng, Wang & Wang, 2014, Constant & Pham, , and the second belongs to Distant, 1906, Meng, Wang & Wang, 2014. was previously recorded from Hainan Island, China.

The tropiduchid planthopper genus Wang & Bourgoin, 2015: two new species from Central Vietnam and new records (Hemiptera, Fulgoromorpha, Tropiduchidae).

Two new planthopper species of the tropiduchid genus Wang & Bourgoin, 2015, Constant & Pham, , and Constant & Pham, are described from Bach Ma National Park and from the Centre for Conservation of Vietnam Natural Resources and Rescue of Animals and plants, Phong Dien District in Thua Thien-Hue Province, respectively. These new records greatly extend the distribution of the genus, which was known from southern China (Guangxi) and North Vietnam, to the south, reaching the mid area of Central Vietnam. New records are provided for Wang & Zhang, 2015, extending the distribution of the species from Cat Ba Island to a large zone in North Vietnam.

Review of the lanternfly genus Pyrops of Thailand (Hemiptera: Fulgoridae) with notes and keys to species.

Fourteen species of the lanternfly genus Pyrops Spinola were documented from Thailand during expeditions across the country and from citizen scientists records. The distribution maps of each species are provided, based on the examined material and records from iNaturalist citizen science platform. The species are illustrated and an identification key is also provided.

Rethinking, reducing, and refining the classical oral tyramine challenge test of monoamine oxidase (MAO) inhibitors.

The oral tyramine challenge evaluates the safety of novel monoamine oxidase (MAO) inhibitors when taken with tyramine-containing food or drinks. In its current design, it comprises an extensive series of tyramine escalation steps until a blood pressure threshold is met. Due to the high variation in tyramine bioavailability, and thereby in blood pressure effect, this classical design has various limitations, including safety concerns.

Parahiraciini planthoppers with elongate head from Vietnam: a new genus and species gen. et sp. nov. and first record of Constant, 2021 (Hemiptera, Fulgoromorpha, Issidae).

The new genus is described to accommodate a new species, from Pu Mat National Park in Vietnam. The new genus is placed in the subtribe Parahiraciina of the Parahiraciini. It is compared with the genera Constant, 2021, Che, Zhang et Wang, 2012, Che, Zhang et Wang, 2011, and Che, Zhang et Wang, 2020 with which it shares possessing an elongate head.

Revision of a unique Australian leafhopper genus Stenopsoides Evans (Hemiptera: Cicadellidae: Idiocerinae: Macropsini).

The Australian genus Stenopsoides Evans (Idiocerinae: Macropsini) is revised. The type species, S. turneri Evans, is redescribed and three new species are added: S.

Characterization, Comparative Analysis and Phylogenetic Implications of Mitogenomes of Fulgoridae (Hemiptera: Fulgoromorpha).

The complete mitogenomes of nine fulgorid species were sequenced and annotated to explore their mitogenome diversity and the phylogenetics of Fulgoridae. All species are from China and belong to five genera: Spinola, 1839 ( sp.); Wang and Huang, 1989 ( Wang and Huang, 1989); Stål, 1863 ( sp.

, the hidden leaf insects - descriptions of a new leaf insect genus and thirteen species from the former celebicum species group (Phasmatodea, Phylliidae).

While the leaf insects (Phylliidae) are a well-supported group within Phasmatodea, the genus Illiger, 1798 has repeatedly been recovered as paraphyletic. Here, the Phyllium (Phyllium) celebicum species group is reviewed and its distinctiveness from the remaining Phylliini genera and subgenera in a phylogenetic context based on morphological review and a phylogenetic analysis of three genes (nuclear gene 28S and mitochondrial genes COI and 16S) from most known and multiple undescribed species is shown. A new genus, , is erected to partially accommodate the former members of the species group.

Pharmacology-Guided Rule-Based Adaptive Dose Escalation in First-in-Human Studies.

First-in-human (FIH) studies typically progress through cohorts of fixed, standard size throughout the escalation scheme. This work presents and tests a pharmacology-guided rule-based adaptive dose escalation design that aims at making "best use" of participants in early clinical drug evaluation; it is paper based, not requiring real-time access to computational methods. The design minimizes the number of participants exposed to dose levels with low likelihood of being therapeutically relevant.

First record of the cicadas genus Orientopsaltria Kato, 1944 (Hemiptera: Cicadidae) from Vietnam, with description of one new species.

A new species of cicada, Orientopsaltria dongnaiensis sp. nov., (Hemiptera: Cicadidae) is described from southern Vietnam.

A new species and first record of the cicada genus Sinotympana Lee, 2009 (Hemiptera: Cicadidae: Dundubiini) from Vietnam.

The first record of the genus Sinotympana Lee, 2009 from Vietnam is presented. Sinotympana caobangensis sp. nov.

Science-based Ethnic Bridging in Drug Development; Review of Recent Precedence and Suggested Steps Forward.

Background: Exposure, safety and/or efficacy of drugs are subject to potential differences between human races or ethnicities, as acknowledged by regulatory guidance and by label texts of various, but not all approved drugs.

Objective: The objective of the present review was to assess recent regulatory precedence on drug use and race or ethnicity, with the goal of identifying opportunities for increasing the informative value of clinical ethnic or racial bridging in drug development.

Methods: Recently, (January 2014-July 2018) FDA approved drug product label texts and approval packages were reviewed for claims, comments and underlying data on use of the product in specific ethnic or racial groups.

Does Previous Breast Reduction Affect the Outcome of Gender-Affirming Subcutaneous Mastectomy?

Introduction: Despite the rising popularity of subcutaneous mastectomy (top surgery) in patients born female and identifying as male or nonbinary, there are limited studies on how prior breast surgeries affect subcutaneous mastectomy. This study evaluates if previous breast reduction affected subcutaneous mastectomy in this patient population.

Methods: The case series consists of 5 patients who, having had prior breast reductions, elected to have subcutaneous mastectomy.

Tetrodotoxin for Moderate to Severe Cancer-Related Pain: A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel-Design Trial.

Objective: This study evaluated subcutaneous injections of tetrodotoxin (TTX) for the treatment of moderate to severe, inadequately controlled cancer-related pain.

Methods: Eligible patients were randomized to receive TTX (30 g) or placebo subcutaneously twice daily for four consecutive days. Efficacy was assessed using pain and composite endpoints (including pain and quality of life measures), and safety was evaluated using standard measures.

Nuclear Magnetic Resonance Solution Structure of DNA Featuring Clustered 2'-Deoxyribonolactone and 8-Oxoguanine Lesions.

Ionizing radiation, free radicals, and reactive oxygen species produce hundreds of different DNA lesions. Clustered lesions are typical for ionizing radiation. They compromise the efficiency of the base excision repair (BER) pathway, and as a consequence, they are much more toxic and mutagenic than isolated lesions.

Cicada genus Pomponia Stål, 1866 (Hemiptera: Cicadidae) from Vietnam and Cambodia, with a new species, a new record, and a key to the species.

The genus Pomponia Stål, 1866 from Vietnam and Cambodia is reviewed . Pomponia brevialata Lee & Pham, sp. nov.

A new chemical inhibitor of angiogenesis and tumorigenesis that targets the VEGF signaling pathway upstream of Ras.

The efficacy of anti-angiogenic therapies on cancer patients is limited by the emergence of drug resistance, urging the search for second-generation drugs. In this study, we screened an academic chemical library (DCM, University of Grenoble-Alpes) and identified a leader molecule, COB223, that inhibits endothelial cell migration and proliferation. It inhibits also Lewis lung carcinoma (LLC/2) cell proliferation whereas it does not affect fibroblast proliferation.

Extreme convergence in egg-laying strategy across insect orders.

The eggs of stick and leaf insects (Phasmatodea) bear strong resemblance to plant seeds and are commonly dispersed by females dropping them to the litter. Here we report a novel egg-deposition mode for Phasmatodea performed by an undescribed Vietnamese species of the enigmatic subfamily Korinninae that produces a complex egg case (ootheca), containing numerous eggs in a highly ordered arrangement. This novel egg-deposition mode is most reminiscent of egg cases produced by members of unrelated insect orders, e.

Synthetic access to the chemical diversity of DNA and RNA 5′-aldehyde lesions.

Hydrogen atom abstraction from the C5′-position of nucleotides in DNA results in direct strand scission by generating alkali-labile fragments from the oxidized nucleotide. The major damage consists in a terminus containing a 5′-aldehyde as part of an otherwise undamaged nucleotide. Moreover it is considered as a polymorphic DNA strand break lesion since it can be borne by any of the four nucleosides encountered in DNA.

The cicada genus Karenia Distant, 1888 (Hemiptera: Cicadidae), with description of a new species.

The cicadas of the genus Karenia are reviewed, and Karenia tibetensis sp.nov. (Hemiptera: Cicadidae) is described from Tibet, China.