Publications by authors named "Constance Couture"
Article Synopsis
- The PHEX gene encodes a protein involved in regulating phosphate levels and is linked to X-linked hypophosphataemia due to mutations.
- Studies using specialized peptide libraries revealed that PHEX requires acidic amino acids, especially aspartate, for effective substrate hydrolysis, while other amino acids in specific positions can inhibit the process.
- The research also identified potential physiological substrates for PHEX, showing that it has a distinct substrate specificity that is different from neprilysin.
