Publications by authors named "Conrado J Simison"
Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy was described for the first time in 2016. The most common clinical manifestation is meningoencephalomyelitis associated with a characteristic imaging pattern that allows diagnostic suspicion and its confirmation through determination of antibodies in serum and cerebrospinal fluid (CSF). We present a case of a 35-year-old patient with involvement of the central and peripheral nervous system and a recent diagnosis of thyroid cancer, which compared to the compatible clinical picture of meningoencephalomyelitis, characteristic findings on MRI and after the exclusion of alternative pathologies, we finally arrived at the diagnosis by the positive determination of anti-GFAP in CSF.
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- The study examined cases of Guillain-Barré syndrome (GBS) following COVID-19 vaccination compared to non-vaccinated GBS cases in Buenos Aires, involving 91 patients treated from March 2020 to March 2022.
- Patients who had been vaccinated showed a higher incidence of cranial nerve involvement and bilateral facial paralysis, but overall clinical severity scores and other neurophysiological characteristics were similar between the two groups.
- The findings suggest a need for further research to clarify any potential link between COVID-19 vaccination and GBS, particularly through ongoing vaccine safety monitoring and epidemiological studies.