Antibiotics (Basel)
January 2025
: Antibiotic-resistant represents a growing threat in the modern world, and new antibiotic targets are needed for its successful treatment. One such potential target is the pyridoxal-5'-phosphate (PLP)-dependent cysteine desulfurase (SufS) of the SUF-like iron-sulfur (Fe-S) cluster biogenesis pathway upon which relies exclusively for Fe-S synthesis. The current methods for measuring the activity of this protein have allowed for its recent characterization, but they are hampered by their use of chemical reagents which require long incubation times and may cause undesired side reactions.
View Article and Find Full Text PDFExposure to low-dose ionizing radiation can have positive impacts on biological performance-a concept known as hormesis. Although radiation hormesis is well-documented, the predominant focus has been medical. In comparison, little research has examined potential effects of early life radiation stress on organismal investment in life history traits that closely influence evolutionary fitness (eg, patterns of growth, survival, and reproduction).
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