Publications by authors named "Connor Celum"
This paper proposes a trial design for locating group-specific doses when groups are partially or completely ordered by dose sensitivity. Previous trial designs for partially ordered groups are model-based, whereas the proposed method is model-assisted, providing clinicians with a design that is simpler. The proposed method performs similarly to model-based methods, providing simplicity without losing accuracy.
View Article and Find Full Text PDFArticle Synopsis
- The paper introduces a new design for phase-I clinical trials that uses ordinal toxicity to determine the best doses for different patient groups, especially when their sensitivity levels are known before the trial starts.
- Unlike previous approaches that either focused on group data or ordinal toxicity independently, this new method effectively combines both to improve the dose-finding process.
- Simulations show that the proposed method reduces the likelihood of dose recommendation reversals and leads to better patient allocation and optimal dose selection throughout the trial.