Publications by authors named "Connor Barrett"
Study Design: Retrospective cohort study.
Objective: To investigate the correlation between comorbid chronic obstructive pulmonary disease (COPD), asthma, tobacco use, and the incidence of postoperative hematoma requiring reoperation after anterior cervical discectomy and fusion (ACDF).
Summary Of Background Data: Prior studies have identified general risk factors such as multilevel fusion and coagulopathy.
Study Design: Retrospective cohort study.
Objective: The purpose of this study was to (1) evaluate recent trends in the use of intraoperative neuromonitoring (IONM) for anterior cervical discectomy and fusion (ACDF) in the United States, (2) assess regional variations in the use of IONM, and (3) assess the association between IONM and clinical outcomes.
Summary Of Background Data: IONM is frequently used during anterior cervical procedures to mitigate the risk of neurological injury.
Article Synopsis
- The study examined how preoperative aortic insufficiency (AI) affects the durability of autografts in children and adolescents undergoing the Ross procedure, between 1993 and 2020.
- It found that those with AI had a significantly higher incidence of severe AI or the need for autograft reintervention (39.0%) compared to those with aortic stenosis (8.8%) after 15 years.
- The research indicated that the annulus (the part of the heart where the autograft is placed) dilated more quickly in the AI group, suggesting that a technique to stabilize the annulus may be necessary for young patients, similar to what is done for adults.
Exonic circular RNAs (circRNAs) produce predominantly non-coding RNA species that have been recently profiled in many tumors. However, their functional contribution to cancer progression is still poorly understood. Here, we identify the circRNAs expressed in soft tissue sarcoma cells and explore how the circRNAs regulate sarcoma growth in vivo.
View Article and Find Full Text PDFWe have been developing CRISPR-directed gene editing as an augmentative therapy for the treatment of non-small cell lung carcinoma (NSCLC) by genetic disruption of Nuclear Factor Erythroid 2-Related Factor 2 (NRF2). NRF2 promotes tumor cell survival in response to therapeutic intervention and thus its disablement should restore or enhance effective drug action. Here, we report how NRF2 disruption leads to collateral damage in the form of CRISPR-mediated exon skipping.
View Article and Find Full Text PDFEwing's sarcoma (ES) is a pediatric sarcoma caused by a chromosomal translocation. Unlike in most cancers, the genomes of ES patients are very stable. The translocation product of the EWS-FLI1 fusion is most often the predominant genetic driver of oncogenesis, and it is pertinent to explore the role of epigenetic alterations in the onset and progression of ES.
View Article and Find Full Text PDFThe brain demands a significant fraction of the energy budget in an organism; in humans, it accounts for 2% of the body mass, but utilizes 20% of the total energy metabolized. This is due to the large load required for information processing; spiking demands from neurons are high but are a key component to understanding brain functioning. Astrocytic brain cells contribute to the healthy functioning of brain circuits by mediating neuronal network energy and facilitating the formation and stabilization of synaptic connectivity.
View Article and Find Full Text PDFBackground: Atrioesophageal fistula (AEF) is a rare but serious adverse event of atrial fibrillation (AF) ablation.
Objective: To identify the clinical characteristics of AEF following ablation procedures for AF and determine the associated mortality.
Methods: A systematic review of observational cases of AEF following ablation procedures for AF was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement protocol.