Publications by authors named "Connor B Hogan"
Branching morphogenesis couples cellular differentiation with development of tissue architecture. Intrahepatic bile duct (IHBD) morphogenesis is initiated with biliary epithelial cell (BEC) specification and eventually forms a heterogeneous network of large ducts and small ductules. Here, we show that is required for developmental establishment of small ductules.
View Article and Find Full Text PDFSox9 Defines Biliary Epithelial Heterogeneity Downstream of Yap Activity.
Cell Mol Gastroenterol Hepatol
March 2022
Article Synopsis
- Researchers found that Sox9 levels in intrahepatic biliary epithelial cells (BECs) can be linked to distinct cell types in the liver using a transgenic mouse model with green fluorescent protein (GFP) expression.
- Various methods were employed, such as immunofluorescence and flow cytometry, to analyze different GFP populations and their response to specific treatments, revealing differences in growth and survival rates of BECs.
- The study concluded that Sox9 expression is a helpful indicator of BEC diversity and Yap activity, and it could be utilized to study specific functions of liver cell subpopulations more effectively.