Malignant histiocytosis of the intestine: a T-cell lymphoma.

Malignant lymphoma complicating coeliac disease has been characterised on morphological and immunocytochemical grounds as malignant histiocytosis of the intestine (MHI). Fresh tissue from four cases of MHI was studied by means of a panel of monoclonal antibodies; in three cases tumour DNA was studied for immunoglobulin and T-cell receptor (TCR) gene rearrangement. Immunocytochemistry showed a T-cell phenotype in all four cases, confirmed by the demonstration of a rearranged TCR beta-chain gene in the three cases studied.

A simple method of exercise testing patients with ventilatory impairment on the bicycle ergometer.

The relationship between symptoms and objective findings is often poor in patients with ventilatory impairment and reduction in exercise tolerance. It is often difficult to know at what level to set the task, when attempting to do submaximal exercise evaluation in such patients. A method for assessing whether performance is appropriate for ventilation, which would also predict a reasonable level to set a submaximal exercise test, would be of value.

The aetiology of sport injuries. A review of methodologies.

Although participation in many sporting activities has increased dramatically in recent years, the study of injuries sustained during training or participation is still in its infancy. The most commonly used strategy is to describe the characteristics of a suitable case-series. This approach is relatively easy to implement, can be used to estimate the total morbidity load in a population, and can identify the relative frequency of various types of injury.

A comparison of three methods of measuring broncholability in asthmatics, bronchitic cigarette smokers and normal subjects.

Bronchial lability was measured in 10 normal subjects, 33 typical asthmatics, and 23 smokers with ventilatory defect, by three different methods in the course of a week. There was little difference between exercise/bronchodilator lability index, spontaneous diurnal variation, and histamine challenge in detecting bronchial lability. It was possible that histamine challenge was more sensitive and more specific to asthma.

Renal carcinoma with staghorn calculus, perinephric abscess, and xanthogranulomatous pyelonephritis in same kidney. Subcutaneous abscess of thigh as initial presentation.

A case is reported of the simultaneous occurrence of renal carcinoma with staghorn calculus, perinephric abscess, and xanthogranulomatous pyelonephritis in the same kidney, with subcutaneous abscess of the thigh as the initial presentation. The coexistence of these diseases in the same kidney would seem to be important since they are frequently confused with each other.

Management of asthma in out-patients.

Five hundred and twenty-nine patients attended five different clinics supervised in three different ways in two adjacent, but socially different, health districts. Performance was apparently better in the clinics supervised by the consultant personally or by specialised junior staff. Non-atopic asthma appeared to be more frequent in clinics attended by patients with a social advantage, where it also appeared to be more easily controlled.

HLA type of patients with coeliac disease and malignancy in the west of Ireland.

HLA, A, B, and DR typing was done on seven of 10 patients with lymphoma, and six patients with carcinoma, all of whom had a flat small intestinal mucosa. Sixty-nine per cent (nine of 13) had HLA B8 and 71% (five of seven) had DR3. The corresponding levels for the local coeliac population are 76% and 84% respectively and the local non-coeliac population 43% and 44%.

The effect of bronchodilators on diurnal rhythms in airway obstruction.

A previous study suggested that bronchodilators were more effective in preventing diurnal variation of peak expiratory flow rate (PEFR) in patients with chronic obstructive bronchitis than asthma (Connolly 1979). In a further investigation of 100 patients there was an association between characteristic patterns and the size of the morning dip. After the use of bronchodilators there was a residual morning dip which was large enough to produce a regular pattern in most asthmatics but few bronchitics.