Publications by authors named "Congzhou Mike Sha"
Nat Methods
December 2024
Article Synopsis
- - RNA-Puzzles is a collaborative project focused on improving the prediction of RNA three-dimensional structures, with predictions made by modeling groups before experimental structures are published.
- - A significant set of predictions was made by 18 groups for 23 different RNA structures, including various elements like ribozymes and aptamers.
- - The study highlights key challenges in RNA modeling, such as identifying helix pairs and ensuring proper stacking, and notes that some top-performing groups also excelled in a separate competition (CASP15).
Article Synopsis
- * The study revealed the SOD1 trimer interactome, identifying binding partners in the brain, spinal cord, and skeletal muscle that may affect cellular functions such as synaptic function and metabolism.
- * Key findings point to specific genes and proteins related to SOD1 trimers, suggesting potential connections between genetic factors and disease mechanisms in ALS.
