Publications by authors named "Congyue Ma"
Chiral P,N-ligands are of great interest and importance in the fields of metal-catalyzed enantioselective transformations and have found numerous applications spanning drug and polymer synthesis. Here, modular assembly of diverse P-stereogenic and axially chiral phosphinooxazoles ligands is achieved through palladium-catalyzed asymmetric cleavage of C-P bond/intermolecular C-H bond functionalization in high atroposelectivities and diastereoselectivities of up to >99% ee and >25:1 dr. This protocol features broad substrate scope and provides an avenue for facile construction of new P-stereogenic and axially chiral phosphinooxazoles ligands directly from the phosphonium salts and benzoxazoles/benzothiazoles.
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- Chiral monodentate biaryl phosphines (MOPs) have gained popularity as effective chiral ligands, but creating a variety of these compounds with both P- and axial chirality remains a complex challenge.
- The authors present a new strategy that utilizes enantioselective C-P bond cleavage to synthesize a diverse range of MOPs featuring both types of chirality.
- The resulting MOPs demonstrate excellent performance as catalysts in the asymmetric reaction of MBH carbonate, producing chiral functionalized bicyclic imides with high selectivity and efficiency.