Salt-Concentrated Electrolyte Constructing High Elasticity Modulus Interphase for Li-Rich Layered Oxide Cathode.

Stable electrolytes are urgently required for lithium-ion batteries based on lithium-rich layered oxides (LLOs), which generally suffer from fast capacity and voltage decay at high voltages up to 4.8 V. Herein, we report a salt-concentrated electrolyte consisting of 4 M lithium hexafluorophosphate (LiPF) salt in ester solvents of fluoroethylene carbonate (FEC) and dimethyl carbonate (DMC) to alleviate the above challenges.

Exploring resting-state EEG oscillations in patients with Neuromyelitis Optica Spectrum Disorder.

Background And Objective: Quantitative resting-state electroencephalography (rs-EEG) is a convenient method for characterizing the functional impairments and adaptations of the brain that has been shown to be valuable for assessing many neurological and psychiatric disorders, especially in monitoring disease status and assisting neuromodulation treatment. However, it has not yet been explored in patients with neuromyelitis optica spectrum disorder (NMOSD). This study aimed to investigate the rs-EEG features of NMOSD patients and explore the rs-EEG features related to disease characteristics and complications (such as anxiety, depression, and fatigue).

The role of basal ganglia network in neural plasticity in neuromyelitis optica spectrum disorder with myelitis.

Objectives: To explore the alternation of the brain baseline activity in neuromyelitis optica spectrum disorder (NMOSD) patients after myelitis, and characterize the representation of the neural plasticity process.

Methods: Clinical evaluation and resting-state fMRI were obtained from 20 NMOSD patients with myelitis and 20 healthy controls, matched in gender and age. Resting-state networks (RSNs) were identified through independent component analysis (ICA), and functional connectivity (FC) intra-RSNs and between region-of-interest (ROI) seed to whole-brain voxels were analyzed.

Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development.

Decreased expression but increased activity of PDK1 has been observed in neurodegenerative disease. To study function of PDK1 in neuron survival during cortical development, we generate forebrain-specific conditional knockout (cKO) mice. We demonstrate that cKO mice display striking neuron loss and increased apoptosis.

Stability of HIB-Cul3 E3 ligase adaptor HIB Is Regulated by Self-degradation and Availability of Its Substrates.

The HIB-Cul3 complex E3 ligase regulates physiological homeostasis through regulating its substrate stability and its activity can be modulated by changing HIB abundance. However, regulation of HIB remains elusive. Here we provide evidence that HIB is degraded through the proteasome by Cul3-mediated polyubiquitination in K48 manner in Drosophila.

Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain.

Background: Tau hyperphosphorylation plays a critical role in neurodegenerative diseases [EMBO Mol Med. 6:1142-60, 2014; Annu Rev Neurosci. 24:1121-59, 2001].

Minocycline reduces neuroinflammation but does not ameliorate neuron loss in a mouse model of neurodegeneration.

Minocycline is a broad-spectrum tetracycline antibiotic. A number of preclinical studies have shown that minocycline exhibits neuroprotective effects in various animal models of neurological diseases. However, it remained unknown whether minocycline is effective to prevent neuron loss.

Age-dependent neuron loss is associated with impaired adult neurogenesis in forebrain neuron-specific Dicer conditional knockout mice.

Impairment in the microRNA (miRNA) network causes a number of neurodegenerative diseases. Endoribonuclease Dicer is a key RNase to produce mature miRNAs. It has been shown that Dicer is important for the maintenance of excitatory neuron survival during early postnatal period.