Unraveling the potential of neuroinflammation and autophagy in schizophrenia.

Schizophrenia (SCZ) is a complex and chronic psychiatric disorder that affects a significant proportion of the global population. Although the precise etiology of SCZ remains uncertain, recent studies have underscored the involvement of neuroinflammation and autophagy in its pathogenesis. Neuroinflammation, characterized by hyperactivated microglia and markedly elevated pro-inflammatory cytokines, has been observed in postmortem brain tissues of SCZ patients and is closely associated with disease severity.

[Preparation and characterization of anti-human IL-15 monoclonal antibody].

Aim: To prepare monoclonal antibody (mAb) against human interleukin-15 (hIL-15) and identify its characterization.

Methods: The GST-IL-15 was extracted from the gene-engineering bacteria E. coli and identified by SDS-PAGE.