Structural characterization and hypolipidemic activity of a natural polysaccharide from Suaeda salsa L.

Herein, the identification and analysis of a newly discovered hypolipidemic polysaccharide extracted from Suaeda salsa L., SS3-N1, is reported. The weight-average molecular weight (Mw), number-average molecular weight (Mn), and dispersity (Ð) of SS3-N1 were determined to be 45.

A polysaccharide from salviae miltiorrhizae radix inhibits weight gain of mice with high-fat diet via modulating intestinal bacteria.

Background: Obesity, a global chronic disease, has been recognized as a severe risk to health. In our study, a novel polysaccharide named ARS was isolated and purified from aerial part of salviae miltiorrhizae radix. Our aim is to investigate the weight-reducing effect of a polysaccharide from salviae miltiorrhizae radix on mice fed a high-fat diet.

A simple and rapid strategy for monitoring vancomycin concentration in serum using a multicolor immunosensor based on the ratio of gold nanobipyramids and a product of cetyltrimethylammonium bromide-blue oxide of 3,3',5,5'-tetramethylbenzidine interaction.

Rapid and simple monitoring of vancomycin (VAN) concentration in blood is a vital strategy for maximizing therapeutic efficacy, minimizing toxicity and developing a personalized treatment plan. In this work, a simple multicolor immunosensor is proposed to enable rapid monitoring of VAN concentration in serum, without using any expensive and bulky instrument. The multicolor immunosensor platform is a system that works based on the principle that the product of cetyltrimethylammonium bromide-blue oxide of 3,3',5,5'-tetramethylbenzidine interaction (CTAB/TMB) and TMB increases simultaneously with the decrease in VAN concentration, whereas AuNBPs are insensitive to VAN.

Development, validation, and use of a monitoring method for fipronil and its metabolites in chicken eggs by QuEChERS with online-SPE-LC-Q/Orbitrap analysis.

Rationale: The residues of fipronil and its metabolites in chicken eggs pose a threat to human health, so regular monitoring is necessary. However, the pretreatments of the existing detection methods are complex and time-consuming. A simple and streamlined pretreatment method is needed to improve the detection efficiency.

Environmental geochemical baseline determination and pollution assessment of heavy metals in farmland soil of typical coal-based cities: A case study of Suzhou City in Anhui Province, China.

Soil is the foundation of agricultural green development and human survival; the study of local environmental geochemical baselines can guide soil management and ensure the safe use of soil. In this study, a total of 100 shallow farmland soil samples were collected in each township of Yongqiao District, Suzhou City, Anhui Province, China. Herein, the contents of 10 heavy metal elements including As, Hg, Cd, Pb, Cr, Cu, Mn, Ni, Zn and Fe were determined.

Design and Synthesis of Scopoletin Sulfonate Derivatives as Potential Insecticidal Agents.

(1) Background: Scopoletin and scoparone, two naturally occurring coumarins, have garnered considerable attention and have been introduced to the market in China due to their high insecticidal efficacy and low toxicity. To investigate the structure-activity relationship of these coumarins, a series of scopoletin derivatives with aryl sulfate at C7 and different substitutes at C3 were designed and synthesized, and their insecticidal activity was studied. (2) Methods: A total of 28 new scopoletin derivatives were designed and synthesized.

Ameliorative effect of polysaccharide selenium nanoparticles against carbon tetrachloride induced oxidative stress and inflammation.

polysaccharide (BRP) extracted as capping agents was applied to prepare BRP-selenium nanoparticles (BRP-SeNPs) in the redox reaction system of sodium selenite and ascorbic acid. The stability and characterization of BRP-SeNPs were investigated by physical analysis method. The results revealed that BRP were tightly wrapped on the surface of SeNPs by forming C-O⋯Se bonds or hydrogen bonding interaction (O-H⋯Se).

Flood Routing Model Coupled with Dynamic Leakage Losses for Ephemeral Rivers with Large Potholes.

Ephemeral rivers commonly occur in regions with a shortage of water resources, and their channel configuration tends to change substantially owing to long drying times and artificial sand extraction. During short-term water conveyance, water storage in large potholes and leakage along the dry riverbed retards the flow, which is detrimental for the river landscape and ecological water demand. The objective of this study is to evaluate the flow process corresponding to a certain release scheme.

Evaluation of Poly(ADP-ribose) Polymerase Inhibitor, Pamiparib (BGB-290) in Treating Acute Myeloid Leukemia and the Characterization of Its Nanocarrier.

Despite the continuous improvement of leukemia treatment in the clinic, the overall 5-year disease-free survival of acute myeloid leukemia (AML) is only approximately 30%-60% due to relapse and the refractoriness of AML after traditional chemotherapy. Inhibition of poly(ADP-ribose) polymerase (PARP), a member of the DNA damage repair complex, has a strong antitumor effect in solid tumors. However, the role of PARP in AML remains unclear.

An automated streamlined method for the therapeutic drug monitoring of digoxin based on the online-solid-phase extraction liquid chromatography tandem high-resolution mass spectrometry.

Rationale: Digoxin is widely used in the clinical treatment of cardiovascular diseases. However, due to its extremely narrow therapeutic window, therapeutic drug monitoring (TDM) is vitally important. In consideration of the time-consuming and labor-intensive nature of the traditional techniques, an automated and efficient method was required for the clinical individualized TDM of digoxin.

Statistical Inference for Periodic Self-Exciting Threshold Integer-Valued Autoregressive Processes.

This paper considers the periodic self-exciting threshold integer-valued autoregressive processes under a weaker condition in which the second moment is finite instead of the innovation distribution being given. The basic statistical properties of the model are discussed, the quasi-likelihood inference of the parameters is investigated, and the asymptotic behaviors of the estimators are obtained. Threshold estimates based on quasi-likelihood and least squares methods are given.

Acid rain leaching behavior of Zn-contaminated soils solidified/stabilized using cement-soda residue.

Cement-soda residue (CSR) has been proven to be an effective binder for treating heavy metal-contaminated soils, and the durability is its most important characteristic. In this study, the effects of acid rain (AR) on the leaching behavior of CSR-solidified/stabilized, zinc-contaminated soils were investigated using flexible-wall soil column leaching tests. After leaching, some parameters were determined such as the unconfined compressive strength (UCS) and permeability coefficient of the samples, the concentrations of Zn and Ca in the filtrate.

A Solid-State Fluorescence Switch Based on Triphenylethene-Functionalized Dithienylethene With Aggregation-Induced Emission.

The development of novel dithienylethene-based fluorescence switches in the aggregated state, and the solid state is highly desirable for potential application in the fields of optoelectronics and photopharmacology. In this contribution, three novel triphenylethene-functionalized dithienylethenes have been designed and prepared by appending triphenylethene moieties at one end of dithienylethene unit. Their chemical structures are confirmed by H NMR, C NMR, and HRMS (ESI).

Circulating Tumor Cells as a Biomarker to Assist Molecular Diagnosis for Early Stage Non-Small Cell Lung Cancer.

Background And Objective: Compared with tissue biopsy, liquid biopsy is the most preferable non-invasive promising method in personalized medicine, although it has many limitations in isolating circulating tumor cells (CTC). Lung cancer associated mortality is drastically increased due to a shortfall of early-stage detection, which remains a challenge. Herein, we aimed to detect lung cancer at an early-stage using CellCollector device.

An integrated strategy for rapid on-site screening and determination of prometryn residues in herbs.

We produced a prometryn-specific monoclonal antibody and propose a strategy for convenient on-site detection of prometryn residues in herbs for the first time. This strategy has perfect applicability in a complex herbal medicine matrix. The strategy combines a semiquantitative immunochromatographic strip assay with a heterologous indirect competitive ELISA.

Distribution and elimination of quinocetone and its major metabolites in Cherry Valley ducks.

We examined the tissue distribution and elimination of quinocetone (QCT) and its major metabolites 1-desoxyquinocetone (1-DQCT), di-desoxyquinocetone (BDQCT), and 3-methyl-quinoxaline-2-carboxylic (MQCA) in ducks. The analytes were simultaneously quantitated using a UPLC-MS/MS method after oral administration of QCT at 100 mg·kg day for 7 days. We found that QCT and its major metabolites were widely distributed in duck tissues.

Development of an online solid-phase extraction-liquid chromatography-mass spectrometric analysis of oxcarbazepine and its active metabolite licarbazepine from plasma with a direct injection step.

We developed an online solid phase extraction procedure using a hydrophilic-lipophilic balance sorbent, with reversed-phase liquid chromatography-high-resolution mass spectroscopy for the determination of oxcarbazepine and its active metabolite licarbazepine in plasma samples. The analytes were detected using a high-resolution Q Orbitrap mass spectrometer with targeted-selected ion monitoring (t-SIM) in positive scan mode. Under the optimized conditions, the method was linear with R values >0.

Recovery Degree of the Natural Flow Regimes and the Corresponding Economic Costs for Reservoir Operation in Fish Spawning Seasons.

The construction of large-scale reservoirs alters the natural flow process downstream and inevitably affects the aquatic organism. Current studies have verified that flow regimes play an important role in fish spawning stimulus. Recovery of the flow regimes may be incompatible with the economic benefit, mainly referring to hydropower generation.

Long noncoding RNA UCA1 as a novel biomarker of lymph node metastasis and prognosis in human cancer: a meta-analysis.

Urothelial carcinoma associated 1 (UCA1), a novel long noncoding RNA (lncRNA) which is first discovered in 2006 in human bladder cancer and has become a hot spot in recent years. UCA1 has been demonstrated correlated with clinical outcomes in various cancers. However, the results from each study are insufficient and not completely consistent.

Rapid identification of triptolide in Tripterygium wilfordii products by gold immunochromatographic assay.

Triptolide colloidal gold immunoassay strip was prepared by using colloidal gold labeled monoclonal antibody purified with saturated ammonium sulfate, triptolide succinate-bovine serum albumin and sheep anti-mouse IgG for the first time in our lab. Under optimized conditions, the detection limit of TP strip prepared in this study were determined to be 1 μg/mL and the total analysis time (including sample preparation) was less than 50 min. Sixty-six batches of Tripterygium wilfordii (T.

A TiO/C catalyst having biomimetic channels and extremely low Pt loading for formaldehyde oxidation.

This study presents a TiO/C hybrid material with biomimetic channels fabricated using a wood template. Repeated impregnations of pretreated wood chips in a Ti precursor were conducted, followed by calcination at 400-600 °C for 4 hours under a nitrogen atmosphere. The generated TiO nanocrystals were homogenously distributed inside a porous carbon framework.

Long Noncoding RNA PVT1 as a Novel Predictor of Metastasis, Clinicopathological Characteristics and Prognosis in Human Cancers: a Meta-Analysis.

The present meta-analysis aimed to systematically evaluates the metastasis, clinical stage, and prognostic value regarding the expression levels of PVT1 in various cancers. Relevant literatures were searched in PubMed、Cochrane Library、Wed of science、Embase databases、Chinese National Knowledge Infrastructure and Wanfang from inception up to 22 August 2017. After data were extracted, a meta-analysis was performed using Review Manager 5.

Efficient Biomass Fuel Cell Powered by Sugar with Photo- and Thermal-Catalysis by Solar Irradiation.

The utilization of biomass sugars has received great interesting recently. Herein, we present a highly efficient hybrid solar biomass fuel cell that utilizes thermal- and photocatalysis of solar irradiation and converts biomass sugars into electricity with high power output. The fuel cell uses polyoxometalates (POMs) as photocatalyst to decompose sugars and capture their electrons.

Fluorometric competitive immunoassay for chlorpyrifos using rhodamine-modified gold nanoparticles as a label.

A new kind of labelled antibody was synthesized by modifying gold nanoparticles (AuNPs) with the fluorophore rhodamine B isothiocyanate (RBITC) and a secondary antibody (IgG). The conjugate thus obtained was used in a competitive sandwich assay with a turn-on signal change. It was designed to detect the organophosphorus pesticide chlorpyrifos.

Development of a broad-specificity antibody-based immunoassay for triazines in ginger and the quantitative structure-activity relationship study of cross-reactive molecules by molecular modeling.

In the present study, molecular modeling and principle component analysis (PCA) were used to select appropriate haptens for group detection of triazine herbicides. Four new structures together with three reported triazine derivatives were chosen for the screening of immunizing and coating haptens. A total of 31 triazines coupled with a 3D-QSAR methodology were employed to investigate the relationship between antigen-antibody recognition and molecular structures, the results of which revealed that the antibodies may recognize triazines from the side of molecules with the distinguishing atom and a steric volume matching with the spatial structure of antibodies.