Progress in the study of antibody-drug conjugates for the treatment of cervical cancer.

Cervical cancer is the second most prevalent malignancy affecting women's health globally, and the number of morbidity and mortality from cervical cancer continues to rise worldwide. The 5-year survival rate of patients with recurrent or metastatic cervical cancer is significantly reduced, and existing treatment modalities have low efficacy and high adverse effects, so there is a strong need for new, effective, and well-tolerated therapies. Antibody-drug conjugates (ADCs) are a new targeted therapeutic modality that can efficiently kill tumor cells.

Robust Scalable-Manufactured Smart Fabric Surfaces Based on Azobenzene-Containing Maleimide Copolymers for Rewritable Information Storage and Hydrogen Fluoride Visual Sensor.

Functionalized materials with reversible color switching are highly attractive in many application fields, especially as rewritable media for information storage. It is critical yet challenging to develop a cost-effective strategy for the fabrication of stimulus-responsive chromogenic systems. Herein, we present a versatile dip-coating approach to fabricate robust smart textile with acid/base-driven chromotropic capability.

The effects of DOPO modified Co-based metalorganic framework on flame retardancy, stiffness and thermal stability of epoxy resin.

In this work, the effect of a modified metal organic framework material on the fire resistance and mechanical properties of epoxy resin (EP) has been explored. The cobalt based metal organic framework (ZIF-67) was synthesized from an organic ligand with a Schiff base structure. Then DOPO@ZIF-67 was synthesized by modifying ZIF-67 with 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO), and its effect on EP modification was explored.

Preparation and Insights of Smart Foams with Phototunable Foamability Based on Azobenzene-Containing Surfactants.

Smart foams with tunable foamability exhibit superb applications in many fields such as colloidal and interface science. Herein, we have synthesized an azobenzene-containing surfactant with excellent photoresponsiveness by a simple thiol-maleimide click reaction between thioglycolic acid and 4-(-maleimide) azobenzene (MAB). The structure and the photoresponsive behavior of the novel surfactant are characterized.

Cytocompatible and non-fouling zwitterionic hyaluronic acid-based hydrogels using thiol-ene "click" chemistry for cell encapsulation.

In this work, a facile click reaction strategy is employed to form hydrogels in situ with cytocompatibility, biodegradability, self-healing property and resistance to protein. The thiol-functionalized zwitterionic carboxybetaine methacrylate copolymer, which take part as a cross-linker in the "thiol-ene" click reaction with the methacrylated hyaluronic acid. The hydrogels are obtained under the physiological condition without the presence of any copper catalyst and UV light.

Safety and complications of medical thoracoscopy in the management of pleural diseases.

Background: Medical thoracoscopy is considered an overall safe procedure, whereas numbers of studies focus on complications of diagnostic thoracoscopy and talc poudrage pleurodesis. We conduct this study to evaluate the safety of medical thoracoscopy in the management of pleural diseases and to compare complications in different therapeutic thoracoscopic procedures.

Methods: A retrospective study was performed in 1926 patients, 662 of whom underwent medical thoracoscopy for diagnosis and 1264 of whom for therapeutic interventions of pleural diseases.

Berberine induces mitochondrial‑mediated apoptosis and protective autophagy in human malignant pleural mesothelioma NCI‑H2452 cells.

Increasing evidence shows that berberine has antitumor effects against a number of tumor cells. In the present study, we evaluated the effect of berberine on the proliferation of the human malignant pleural mesothelioma (MPM) cell line NCI‑H2452, and explored the therapeutic potential and underlying mechanisms of this agent. Our results showed that berberine inhibited the proliferation of NCI‑H2452 cells in a dose‑ and time‑dependent manner and could induce apoptosis, possibly through a caspase‑9‑dependent intrinsic mitochondrial pathway.

Erythromycin poudrage versus erythromycin slurry in the treatment of refractory spontaneous pneumothorax.

Background: Refractory (recurrent or persistent) spontaneous pneumothorax with high recurrence rates required treatment either by continuous chest drainage or interventional approaches. Pleurodesis by sclerosing agents has become a significant therapy in the treatment of refractory spontaneous pneumothorax (RSP) on account of its high efficiency and safety. However, the efficacy, safety and appropriate mode of administration of intrapleural erythromycin for pleurodesis have not yet been realized in the treatment of RSP.

Potential of cross-priming amplification and DNA-based lateral-flow strip biosensor for rapid on-site GMO screening.

The requirement to monitor the presence of genetically modified organisms (GMO) in a variety of marked products has generated an increasing demand for reliable, rapid, and time and cost-effective analytical methods. Here we report an on-site method for rapid detection of cauliflower mosaic virus promoter (CaMV 35S), a common element present in most GMO, using cross-priming amplification (CPA) technology. Detection was achieved using a DNA-based contamination-proof strip biosensor.