High Expression of Serum UCA1 may be a Potential Biomarker for Clinical Diagnosis of Gastric Cancer.

Background: The current study aims to detect the differential expression of lncRNA UCA1 in serum of patients with gastric cancer and a normal control group and to explore its efficacy and significance in clinical diagnosis of gastric cancer.

Methods: The expression of UCA1 in serum of gastric cancer and normal control group was detected by real-time fluorescence quantitative PCR, and its correlation with clinicopathological characteristics of gastric cancer was analyzed. The diagnostic efficacy of UCA1 in gastric cancer was evaluated by ROC curve and risk score analysis, and compared with carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 72-4 (CA72-4), and alpha fetoprotein.

High expression of matrix metalloproteinases 16 is associated with the aggressive malignant behavior and poor survival outcome in colorectal carcinoma.

Recent evidence suggested an important role of matrix metalloproteinases 16 (MMP16) in the progression of several cancers. However, the contribution of MMP16 to colorectal cancer (CRC) remains elusive. In this study, we combined analyzed the MMP16 expression in The Cancer Genome Atlas (TCGA), GSE39582 database and in-house database.

Does overexpression of HER-2 correlate with clinicopathological characteristics and prognosis in colorectal cancer? Evidence from a meta-analysis.

Background: Previous studies have been inconsistent with respect to the reported associations between human epidermal growth factor receptor (HER-2/neu) overexpression in colorectal cancer. The aims of this meta-analysis are to assess its correlation with clinicopathological characteristics and prognostic significance in colorectal cancer.

Methods: Eligible studies were searched in Pubmed, Embase and Web of Science databases.

The value of single-incision laparoscopic surgery for colorectal cancer: a systematic literature review.

Background/aims: Recently, single-incision laparoscopic colectomy (SILC) for colorectal malignancy is rapidly becoming the central issue for explorers of minimally invasive surgery worldwide. The aim of this systematic review was to establish the safety and efficacy of SILC for colorectal malignancy when implemented by experienced surgeons.

Methodology: PubMed, WHO international trial register and Embase were searched for publications concerning SILC and MLC from 2000 to 2013, with the last search on September 10, 2013.

Role of protective stoma in low anterior resection for rectal cancer: a meta-analysis.

Aim: To provide a comprehensive evaluation of the role of a protective stoma in low anterior resection (LAR) for rectal cancer.

Methods: The PubMed, EMBASE, and MEDLINE databases were searched for studies and relevant literature published between 2007 and 2014 regarding the construction of a protective stoma during LAR. A pooled risk ratio (RR) with 95% confidence intervals (CIs) was used to assess the outcomes of the studies, including the rate of postoperative anastomotic leakage and reoperations related to leakage.

The prognostic value of HER-2/neu overexpression in colorectal cancer: evidence from 16 studies.

Human epidermal growth factor receptor (HER-2/neu) plays an important role in the progression of several types of cancer. Numerous studies examining the relationship between HER-2 overexpression and prognostic impact in patients with colorectal cancer have yielded inconclusive results. We therefore conducted a meta-analysis to provide a comprehensive evaluation of the prognostic value of HER-2 expression on the survival, which compared the positive and negative expressions of HER-2 in patients of the available studies.

Retrospective analysis of protective stoma after low anterior resection for rectal cancer with total mesorectal excision: three-year follow-up results.

Background/aims: Anastomotic leakage is a complication of low anterior resection (LAR) for rectal cancer with total mesorectal excision (TME). This study evaluated the need for a protective stoma by a three-year follow-up.

Methodology: A retrospective study of 56 LAR patients was conducted.