Publications by authors named "Congbin Li"
Introduction: Sleep disorders are prevalent and significant among individuals receiving methadone maintenance treatment (MMT), adversely affecting their quality of life and treatment adherence. While cerebral blood flow (CBF) plays a crucial role in the development of various diseases, its relationship with sleep disorders remains uncertain. This observational study focuses on possible correlations between CBF and poor subjective sleep quality in MMT patients.
View Article and Find Full Text PDFIntroduction: Methamphetamine is currently one of the most commonly used addictive substances with strong addiction and a high relapse rate. This systematic review aims to examine the effectiveness of physical activity in improving negative emotions, cognitive impairment, and drug craving in people with methamphetamine use disorder (MUD).
Methods: A total of 17 studies out of 133 found from Embase and PubMed were identified, reporting results from 1836 participants from MUD populations.
Spinal cord injury is a kind of nerve injury disease with high disability rate. The bioscaffold, which presents a biomimetic structure, can be used as "bridge" to fill the cavity formed by the liquefaction and necrosis of spinal nerve cells, and connects the two ends of the fracture to promote the effective recovery of nerve function. Tubasatin A (TUBA) is a potent selective histone deacetylase 6 (HDAC6) inhibitor, which can inhibit the overexpression of HDAC6 after spinal cord injury.
View Article and Find Full Text PDFPalovarotene inhibits the NF-κB signalling pathway to prevent heterotopic ossification.
Clin Exp Pharmacol Physiol
August 2022
Article Synopsis
- - Heterotopic ossification (HO) is a painful and dysfunctional condition that leads to abnormal calcification, with unclear underlying mechanisms; palovarotene, a retinoic acid receptor γ agonist, shows promise in inhibiting HO formation.
- - The study used in vitro and in vivo models to assess HO, finding that inflammatory stimulation increased calcium deposition in bone mesenchymal stem cells (BMSCs) and activated the NF-κB signaling pathway.
- - Palovarotene treatment reversed these effects by blocking the NF-κB cascade, suggesting it could be an effective therapy for HO, although further research on its side effects is needed.
Article Synopsis
- Heterotopic ossification (HO) is the abnormal formation of bone tissue outside of bones, often related to tendon stem cells (TSCs) and influenced by an inflammatory environment, particularly involving macrophages.
- Current treatments for HO, like nonsteroidal anti-inflammatory drugs and radiotherapy, can have significant side effects, highlighting the need for more effective therapies.
- This study investigates the effects of palovarotene, a retinoic acid receptor activator, on reducing HO and its mechanisms, utilizing various experimental models to understand the relationship between TSCs, inflammation, and the Smad signaling pathway.
Traumatic heterotopic ossification (THO) is a serious and common clinical post-traumatic complication for which there is no effective and safe drug treatment. Routine administration of nonsteroidal anti-inflammatory drugs (NSAIDs) after injury is extensively used approach for THO. However, serious adverse events can occur in the event of an overdose of NSAIDs.
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