Publications by authors named "Cong-ye Li"
Article Synopsis
- Diabetic cardiomyopathy (DCM) leads to fatty acid accumulation in the heart, causing lipotoxicity that negatively affects heart function, while Adipsin may help mitigate these effects.
- A study was conducted on mice with a high-fat diet to explore how Adipsin influences DCM and identify its molecular interactions, using various advanced analytical methods.
- Results showed that Adipsin levels decreased in DCM, but increased Adipsin expression improved heart function and mitochondrial health by inhibiting the harmful interaction between Irak2 and key mitochondrial proteins.
As the essential amino acids, branched-chain amino acid (BCAA) from diets is indispensable for health. BCAA supplementation is often recommended for patients with consumptive diseases or healthy people who exercise regularly. Latest studies and ours reported that elevated BCAA level was positively correlated with metabolic syndrome, diabetes, thrombosis and heart failure.
View Article and Find Full Text PDFMacrophages are essential for wound repair after myocardial infarction (MI). CD226, a member of immunoglobulin superfamily, is expressed on inflammatory monocytes, however, the role of CD226 in infarct healing and the effect of CD226 on macrophage remain unknown. Wild type and CD226 knockout (CD226 KO) mice were subjected to permanent coronary ligation.
View Article and Find Full Text PDFDiabetic patients are sensitive to myocardial ischemia-reperfusion (MI/R) injury. During diabetes, branched-chain amino acid (BCAA) catabolism is defective and mitochondrial phosphatase 2C (PP2Cm) expression is reduced. This study aims to elucidate the relationship between PP2Cm downregulation and BCAA catabolism defect in diabetic mice against MI/R injury.
View Article and Find Full Text PDF[Antagonism of LY333531 on high glucose induced permeability upregulation of cardiac microvascular endothelial cells].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
April 2009
Aim: To investigate the antagonism of LY333531 on the increased permeability of cardiac microvascular endothelial cells (CMECs) induced by high glucose.
Methods: The cultured CMECs from rats were randomly divided into four groups: normal group, high glucose group (25 mmol/L), high glucose+LY333531 (10 micromol/L) group and high glucose+saline group. The permeability of cell monolayer was detected using in vitro vascular permeability assay kit.